Turmeric Facial Serum 30ml,Turmeric Dark Spot Corrector Serum,Hydrating Firming Antioxidant,Natural Turmeric Acne Dark Spot Remover,Reduces Fine Lines, Blemishes (30ml-3Pcs)

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The base is a 10% blend of two forms of vitamin C that help deal with dark spots and dullness. Additionally, the serum gets extra antioxidants from turmeric and camu camu extracts. We particularly love turmeric, as it's known as a famous anti-inflammatory and can tame angry skin. Li H, Sureda A, Devkota HP, et al. Curcumin, the golden spice in treating cardiovascular diseases. Biotechnol Adv. 2020;38:107343. doi:10.1016/j.biotechadv.2019.01.010 The most widely used part of turmeric is its root, comprising loads of phytochemicals, vitamins, and minerals, quite beneficial for the cure of various human diseases. It seems that turmeric is a generally safe medicinal herb. However, its use during pregnancy and lactation and in patients with hepatic and renal failure should be assessed critically. Many products are extracted from turmeric. Its most active component, curcumin, followed by other significant components including curcuminoids atlantone, dimethoxycurcumin, diarylheptanoids, tumerone, and flavonoid curcumin (diferuloylmethane) has antimicrobial, anti-inflammatory, and antioxidant properties that provide its protective effect against different types of cellular injury. Moreover, turmeric and its constituents not only provide neuroprotection but also modulate the pathology of neurologic diseases like Parkinson’s and Alzheimer’s diseases. It has also been well documented to be an effective tool against various kinds of cancers. Furthermore, there are several researches on its effects against metabolic syndrome. To sum up, it could be concluded that turmeric and its components are recommended in dietary regimens to combat a wide variety of diseases. Further researches are necessitated for better understanding and judgment on its uses in clinical practice. Furthermore, regarding its constituents’ bioavailability and drug delivery systems, developing modern formulations (e.g., nanoparticles, liposomes, and microspheres) and assessing their efficacy are suggested. Abbreviations C. Longa:

Different spices, including turmeric, have an inevitable role in the prevention and treatment of cardiovascular diseases. Modulating migratory, proliferative, and hypertrophic pathways, prohypertrophic signaling, and proliferation abilities of cardiac fibroblasts are some of the mechanistic aspects of its cardiovascular protection. In addition, it can make a balance between extracellular matrix components’ synthesis and degradation [ 123– 125]. Vitamin C is a potent antioxidant," explains board-certified dermatologist Joshua Zeichner, MD, the director of cosmetic and clinical research at Mount Sinai’s Department of Dermatology in New York City. “It interferes with pigment production and keeps inflammation at bay.” Not only that, but it can also support collagen production. Turmeric and its constituents were examined in many researches for their safety through in vitro studies, animal studies, and clinical trials. According to a comprehensive review on this subject, the administration of standardized powder/extract of turmeric and curcumin via oral route revealed no significant side effects or toxicities to animals. In addition, cell culture studies showed that “ curcumin has antiproliferative effect in normal cells and can reduce cell viability.” However, there were no reports about mutagenicity and genotoxicity. It seems that oral use of turmeric and curcumin in human is safe, even at extraordinary doses. Itching, tongue redness, tachycardia, and gastrointestinal complaints (e.g., flatulence, diarrhea, nausea, and constipation) were reported in a small proportion of cases. It should be noted that there are several problems regarding bioavailability of oral curcumin. However, its intravenous formulations have a greater absorption. Therefore, intravenous curcumin should be administered at lower doses than oral use [ 131].The Pilgrim Vitamin C Night Serum has an anti-aging formula designed for dry and combination skin types. It contains vitamin C that acts as a powerful antioxidant to prevent free radical damage, while vitamin E protects the skin from sun damage. Mortezaee K, Salehi E, Mirtavoos-Mahyari H, et al. Mechanisms of apoptosis modulation by curcumin: Implications for cancer therapy. J Cell Physiol. 2019;234(8):12537-12550. doi:10.1002/jcp.28122 Vitamin C is a skin care staple for many skin care pros—including myself, as a beauty director with a decade of experience in the beauty market. I use vitamin C serums almost every day (I'll switch it up and add another antioxidant serum or a hydrating serum depending on how my skin is feeling). And I've been using the collagen-boosting antioxidant for about eight years now, so I've tried a lot of options out there from natural and clean to traditional. In the current review, nutritional value, the most used products of turmeric, and its biochemistry are briefly discussed. Moreover, there was an attempt not only to highlight the anticancer potential of the turmeric and its components but also to discuss other pharmacological activities by mechanistic details, clinical applications, and safety of turmeric. 2. Nutritional Composition It's also a staple in brightening products since vitamin C can inhibit your skin's melanin production, which is what causes skin discoloration like dark spots and hyperpigmentation, New York City-based board-certified dermatologist Patricia Wexler, MD, previously told Allure. Over time, she says, vitamin C can help prevent dark spots from forming in the first place — in addition to evening out skin tone.

Turmeric contains antioxidants and anti-inflammatory components. These characteristics may provide glow and luster to the skin. Turmeric may also revive your skin by bringing out its natural glow.A schematic diagram representing turmeric’s medicinal attributes regarding some of the most important mechanisms. NF- κB: nuclear factor- κB; STAT3: signal transducer and activator of transcription 3; Nrf2: nuclear factor erythroid 2-related factor 2; SOD: superoxide dismutase; NFAT: nuclear factor of activated T cells; FtsZ: filamenting temperature-sensitive mutant Z; GSH: glutathione; NOS: nitric oxide synthase; ACE: angiotensin-converting enzyme. Furthermore, the role of curcumin in human ectopic endometriotic stromal cells secluded from women with endometriosis has been investigated. It was noted that the treatment of endometriotic stromal cells with curcumin indicated noticeable repression of mRNA expression of ICAM-1 and VCAM-1. Curcumin also drastically diminishes the TNF- α-initiated cell surface and emergence of ICAM-1 and VCAM-1. Moreover, the application of curcumin on the endometriotic stromal cells clearly reduces the TNF- α-initiated discharge of IL-6, IL-8, and monocyte chemoattractant protein-1 (MCP-1). Besides, curcumin subdues the commencement of transcription factor NF- κB in human endometriotic stromal cells [ 40]. C. longa is presently labeled to own tumor inhibiting gears not only in vitro but also in vivo. It has been testified that curcumin can progress the tumor hindering efficiency of docetaxel in lung cancer. Likewise, synchronized administration of curcumin and docetaxel results in slight toxicity to normal tissues as well as the bone marrow and liver [ 53]. 5.6. Blood and Other Cancers Previous research conducted to examine the ability of turmeric to protect against lead-induced harm to the hippocampal cells of male Wistar rats demonstrated that it extensively prevented lipid peroxidation due to the exposure of toxic heavy metals. The reaction between curcumin and metals (cadmium and lead) resulted in formation of complex compounds that showed the effectiveness of curcumin in binding the metals [ 68]. S. Li, W. Yuan, G. Deng, P. Wang, P. Yang, and B. B. Aggarwal, “Chemical composition and product quality control of turmeric ( Curcuma longa L.),” Pharmaceutical Crops, vol. 2, no. 1, 2011.View at: Google Scholar