Apigenin 100mg x 90 Capsules - Third Party Tested Over 98% - Natural Apigenin Supplement Vitality Pro

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K. Nagpal, “Polyphenols in Food: Cancer Prevention and Apoptosis Induction,” Current Medicinal Chemistry, vol. Based on the chemical structure of its backbone, apigenin is a flavone, one of the subclasses of flavonoids. The absorption of flavonoid glycosides from the small intestine involves the glucose transport pathway [ 70].

parapsilosis ATCC 22019 were reported to be inhibited by apigenin with MIC of 8 and 16 μg/mL, respectively [ 100]. K. Sak, “Epidemiological evidences on dietary flavonoids and breast cancer risk: A narrative review,” Asian Pacific Journal of Cancer Prevention, vol. Those reviews include findings relating to the pharmacokinetics, cancer chemo-prevention, and drug interactions of apigenin based on eukaryotic cells, animal models, or epidemiological studies.C. Hollman, “The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides,” British Journal of Nutrition, vol. Apigenin-7- O-glucoside, apigenin, and luteolin, mainly as conjugates, were observed in germ-free rats’ fecal excretion, while they were excreted at a considerably lower level in HMA rats [ 129]. Recently, apigenin has received much attention because it has low intrinsic toxicity [ 4, 44] and it exerts differential effects on normal versus cancer cell growth, survival, or apoptosis in several different types of cells [ 9, 13, 52]. Several reviews are available on the bioactivities of apigenin focusing on different aspects including its health functionality [ 11] and cancer chemoprevention potential [ 9, 10, 13].

Apigenin showed synergistic effects with antitumor drugs such as paclitaxel, 5-fluorouracil, PLX4032 and N-(4-hydroxyphenyl) retinamide by enhancing their bioavailability or efficacy [ 4]. Tukappa, “Antibacterial attributes of apigenin, isolated from Portulaca oleracea L,” International Journal of Bacteriology, vol.As shown earlier in the ADME section of the review, part of the apigenin intake is excreted in the feces and apigenin aglycone was detected in cecum luminal content, thus the bacterial community in the colon is exposed to dietary apigenin. Given the prevalence of antibiotic resistance, apigenin or its derivatives could be a candidate as a new antibiotic or as a dietary supplement to enhance the performance of antibiotics. Yiqing Song, JoAnn E Manson, Julie E Buring, Howard D Sesso, Simin Liu Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis J Am Coll Nutr. In both rats and humans, apigenin has been reported to produce major metabolites of glucuronidated and sulfated conjugates [ 63].