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Oh, S. W. et al. A mesoscale connectome of the mouse brain. Nature 508, 207–214 (2014). This paper reports the first mesoscale connectome of the mouse brain. Ren Z, Pribiag H, Jefferson SJ, Shorey M, Fuchs T, Stellwagen D, et al. Bidirectional homeostatic regulation of a depression-related brain state by gamma-aminobutyric acidergic deficits and ketamine treatment. Biol Psychiatry. 2016;80:457–68. Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, et al. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 2010;329:959–64.

Harony-Nicolas H, Kay M, du Hoffmann J, Klein ME, Bozdagi-Gunal O, Riad M, et al. Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat. eLife. 2017;6:e18904. Erlich JC, Bialek M, Brody CD. A cortical substrate for memory-guided orienting in the rat. Neuron. 2011;72:330–43. Pagani M, Bertero A, Liska A, Galbusera A, Sabbioni M, Barsotti N, et al. Deletion of autism risk gene Shank3 disrupts prefrontal connectivity. J Neurosci. 2019;39:5299–310.Nakazawa K, Jeevakumar V, Nakao K. Spatial and temporal boundaries of NMDA receptor hypofunction leading to schizophrenia. npj Schizophr. 2017;3:7.

Wang X, Gu Z, Zhong P, Chen G, Feng J, Yan Z. Aberrant regulation of NMDA receptors by dopamine D4 signaling in rats after phencyclidine exposure. Mol Cell Neurosci. 2006;31:15–25. Task-specific training was conducted by physical therapists in participants' homes, focusing on walking, sit-to-stand transfers, and standing, twice a week for 8 weeks. Goal attainment scaling was used to individualize the intervention and monitor achievement of personal goals. Zheng Y, Liu A, Wang ZJ, Cao Q, Wang W, Lin L, et al. Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease. Brain. 2019;142:787–807. Kim D, Jeong H, Lee J, Ghim JW, Her ES, Lee SH, et al. Distinct roles of parvalbumin- and somatostatin-expressing interneurons in working memory. Neuron. 2016;92:902–15. Gao WJ, Wang Y, Goldman-Rakic PS. Dopamine modulation of perisomatic and peridendritic inhibition in prefrontal cortex. J Neurosci. 2003;23:1622–30.Yuen EY, Qin L, Wei J, Liu W, Liu A, Yan Z. Synergistic regulation of glutamatergic transmission by serotonin and norepinephrine reuptake inhibitors in prefrontal cortical neurons. J Biol Chem. 2014;289:25177–85. Scheggia D, Managò F, Maltese F, Bruni S, Nigro M, Dautan D, et al. Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice. Nat Neurosci. 2020;23:47–60.

Yuen EY, Liu W, Karatsoreos IN, Feng J, McEwen BS, Yan Z. Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory. Proc Natl Acad Sci USA. 2009;106:14075–9. Pinto L, Dan Y. Cell-type-specific activity in prefrontal cortex during goal-directed behavior. Neuron. 2015;87:437–50. min resistance) and handwriting at home, both were delivered through workbooks with monthly support visits. Primary outcome was a 2†Yuen EY, Liu W, Karatsoreos IN, Ren Y, Feng J, McEwen BS, et al. Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory. Mol Psychiatry. 2011;16:156–70.

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m and with no contraindication to exercise were recruited from the Thames valley, UK, and randomised (1:1) to intervention (exercise) or control (handwriting) groups, via a concealed computer-generated list. Groups received a 6-month, twice weekly programme. Exercise was undertaken in community facilities (30†Pantazatos SP, Huang YY, Rosoklija GB, Dwork AJ, Arango V, Mann JJ. Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity. Mol Psychiatry. 2017;22:760–73. Zingg, B. et al. Neural networks of the mouse neocortex. Cell 156, 1096–1111 (2014). This paper reports population-level connectivity and subnetworks of the mouse cortex. Li YC, Kellendonk C, Simpson EH, Kandel ER, Gao WJ. D2 receptor overexpression in the striatum leads to a deficit in inhibitory transmission and dopamine sensitivity in mouse prefrontal cortex. Proc Natl Acad Sci USA. 2011;108:12107–12.

Lee AT, Cunniff MM, See JZ, Wilke SA, Luongo FJ, Ellwood IT, et al. VIP interneurons contribute to avoidance behavior by regulating information flow across hippocampal-prefrontal networks. Neuron. 2019;102:1223–34.e1224. Objective Advances in computer vision make it possible to combine low-cost cameras with algorithms, enabling biomechanical measures of body function and rehabilitation programs to be performed anywhere. We evaluated a computer vision system's accuracy and concurrent validity for estimating clinically relevant biomechanical measures. Design Cross-sectional study. Setting Laboratory. Participants Thirty-one healthy participants and 31 patients with axial spondyloarthropathy. Intervention a series of clinical functional tests (including the gold standard Bath Ankylosing Spondylitis Metrology Index tests). Each test was performed twice: the first performance was recorded with a camera, and a computer vision algorithm was used to estimate variables. During the second performance, a clinician measured the same variables manually. Main measures Joint angles and inter-limb distances. Clinician measures were compared with computer vision estimates. Results for all tests, clinician and computer vision estimates were correlated ( r2 values: 0.360–0.768). There were no significant mean differences between methods for shoulder flexion (left: 2±14° (mean±standard deviation), t=0.99, p < 0.33; right: 3±15°, t=1.57, p < 0.12), side flexion (left:−0.5±3.1†Stokes MG. ‘Activity-silent’ working memory in prefrontal cortex: a dynamic coding framework. Trends Cogn Sci. 2015;19:394–405. Nava N, Treccani G, Müller HK, Popoli M, Wegener G, Elfving B. The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex. Eur Neuropsychopharmacol. 2017;27:19–28. Bloodgood BL, Sharma N, Browne HA, Trepman AZ, Greenberg ME. The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature. 2013;503:121–5.Yuen EY, Wei J, Liu W, Zhong P, Li X, Yan Z. Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex. Neuron. 2012;73:962–77. Harris, J.A. et al.Hierarchical organization of cortical and thalamic connectivity. Nature 575, 195–202 (2019). This paper reports cell-type specific connectivity of mouse cortex and thalamus.