Solaray, Lithium Aspartate, 5 mg, 100 Capsules

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Inhibiting the GSK3 enzyme may also help maintain healthy glucose levels already within normal range. 5,6 Bourgeois ML, Masson M (2017) The history of lithium in medicine and psychiatry. In: Malhi G, Masson M, Belliver F (eds) The science and practice of lithium therapy. Springer, Cham, pp. 181–188 Lithium orotate: is a salt with orotate, a naturally-occurring substance in the body. Patients taking lithium orotate experience far fewer side-effects compared to lithium medication. This may simply be because lithium orotate is prescribed at much lower doses than the medication. Others have argued that it can enter cells where it is needed, resulting in less toxicity to other organs. Torshin I.Y., Gromova O.A., Ostrenko K.S., Filimonova M.V., Gogoleva I.V., Demidov V.I., Kalacheva A.G. Lithium ascorbate as a promising neuroprotector: fundamental and experimental studies of an organic lithium salt. Molecules. 2022:27. [ PMC free article] [ PubMed] [ Google Scholar] That is why people taking one of the mentioned medications should only take lithium orotate supplements after consulting with a medical professional. Lithium Orotate Side Effects

Guttuso T., Jr., Russak E., De Blanco M.T., Ramanathan M. Could high lithium levels in tobacco contribute to reduced risk of Parkinson's disease in smokers? J. Neurol. Sci. 2019; 397:179–180. [ PubMed] [ Google Scholar]Lithium can take weeks to reach its full effectiveness. For this reason, supplementing lithium medication with healthy anxiety-reducing activities may help you to feel better in the meantime. Knowing about these potential alternatives to medication may help to prevent relapses if you are stopping lithium treatment, and are also useful to know about if you are looking to avoid medication entirely. Lithium carbonate– This form can only be obtained as a prescription medication in most countries. A daily dose often contains about 112 to 225 mg of lithium, which is a significantly higher dose than what is found in lithium supplements. Lithium carbonate is about as safe as lithium orotate or aspartate per milligram but it is responsible for significantly more side effects because lithium orotate and aspartate are usually taken at much lower doses. Krześlak A (2010) Akt kinase: a key regulator of metabolism and progression of tumors. Postepy Hig Med Dosw 64:490–503 Shiotsuki I, Terao T, Takeuchi S, Kuroda Y, Kohno K, Mizokami Y, Hatano K (2016) Trace lithium is inversely associated with male suicide after adjustment of climatic factors. J Affect Disord 189:282–286

Schrag A., Jahanshahi M., Quinn N. What contributes to quality of life in patients with Parkinson's disease? J. Neurol. Neurosurg. Psychiatry. 2000; 69:308–312. [ PMC free article] [ PubMed] [ Google Scholar] The biochemical mechanism of Li action seems to be multifactorial and interdependent with the function of various enzymes, hormones, and vitamins [ 23]. Numerous studies conducted so far on the exact mechanism of its function in the human body still leave many gaps yet to be fully elucidated [ 1, 3, 7]. It is possible that the action of Li + ions in cells is based on competition with Na + and Mg 2+ ions, resulting from the similarity of their atomic radius. It is also postulated that the key to the therapeutic effect of Li lies in the inhibition of enzymes, dependent on the above cations, which regulate intracellular processes and participate in specific nerve transmission pathways. The synthesis and release of neurotransmitters in the cell membrane and the entire cellular metabolism can therefore be modified by the action of Li [ 3, 7, 24, 25]. Heghedus-Mindru G, Biron RK, Pejru DM, Rusnac LM, Rivis A, Stef DS (2008) Cation contents in natural mineral waters of Romania determined with the HPIC method. Food Agr Environ 6:506–508 Anna Fels, professor of psychiatry at Cornell and published in the New York Times, said, “There’s enough evidence that people should have the option of taking micro doses [of lithium], especially since there seemed to be no downside to it … There’s very suggestive evidence that it’s useful in terms of reducing impulsivity, irritability, suicidality.” Clinical Observations: The Benefits of Low Dose Lithium for Depression & Anxiety As this was a pilot study with limited funding, a step-wise approach was used to prioritize the blood-based therapeutic target assessments. In the initial eight patients enrolled, PBMC Nurr1 and SOD1 mRNA, serum BDNF and plasma alpha-synuclein were assessed to determine the most promising blood-based therapeutic targets to assess in the remaining patients. PBMC Nurr1 and SOD1 mRNA were assessed by Taqman quantitative, real-time polymerase chain reaction (ThermoFisher Scientific, Waltham, MA). Values were normalized to actin levels. Serum BDNF was assessed by ELISA kit (R&D Systems, Minneapolis, MN). Plasma alpha-synuclein was assessed by ultra-sensitive, immunomagnetic reduction assay (MagQu, Taiwan). PBMC GSK3β (total and serine 9 phosphorylated (pS9) levels) were assessed by PathScan ELISA kit (Cell Signaling Technology, Danvers, MA) in the patients who had adequate PBMC protein to support these assays. In the final nine patients, only PBMC Nurr1 and SOD1 were assessed as these showed the most promise in the initial eight patients. With this approach, enough funding was preserved to obtain MRI scans at baseline and 24 weeks in six patients receiving lithium (two from each lithium dosage group chosen consecutively).Lithium orotate is sold over the counter because it is a lot less potent than prescription lithium. The reason is due to orotic acid making up for most of the supplement’s weight. In standard dosages, 120 mg supplements contain 4.6 mg of elemental lithium. Most people get about 0.64-3 mg of lithium from food and water daily. This amount is extremely safe and has little to no side effects.

Rybakowski JK, Lehmann W (1994) Decreased activity of erythrocyte membrane ATPases in depression and schizophrenia. Neuropsychobiol 30(1):11–14 Le W., Conneely O.M., Zou L., He Y., Saucedo-Cardenas O., Jankovic J., Mosier D.R., Appel S.H. Selective agenesis of mesencephalic dopaminergic neurons in Nurr1-deficient mice. Exp. Neurol. 1999; 159:451–458. [ PubMed] [ Google Scholar] Ishii N, Terao T, Araki Y, Kohno K, Mizokami Y, Shiotsuki I, Hatano K, Makino M, Kodama K, Iwata N (2015) Low risk of male suicide and lithium in drinking water. J Clin Psychiatry 76(3):319–326 Dorsey E.R., Bloem B.R. The Parkinson pandemic-a call to action. JAMA Neurol. 2018; 75:9–10. [ PubMed] [ Google Scholar] Ayotte JD, Gronberg JM, Apodaca LE (2011) Trace elements and radon in groundwater across the United States, 1992–2003; Investigations Report; U.S. Geological Survey: Reston, VA, USALithium citrate– This is another popular form mainly used as a prescription medication for the treatment of bipolar disease. Is there a role for lithium orotate in psychiatry?” Australian and New Zealand Journal of Psychiatry (2018) You can ask your doctor for a referral to a psychologist or other mental health professional who uses Lovkova MY, Sokolova SM, Buzuk GN (2007) Lithium-concentrating plant species and their pharmaceutical usage. Dokl Akad Nauk 412(5):713–715

As you’ve seen in the previous section, one of the possible lithium orotate side effects, weight gain, is sometimes observed with long-term use. Kim Y.H., Rane A., Lussier S., Andersen J.K. Lithium protects against oxidative stress-mediated cell death in alpha-synuclein-overexpressing in vitro and in vivo models of Parkinson's disease. J. Neurosci. Res. 2011; 89:1666–1675. [ PMC free article] [ PubMed] [ Google Scholar]Ionic lithium: is a liquid form that contains lithium chloride. This form can be especially helpful for children or patients who are sensitive to treatment, as it is easy to start at a low dose and build up to a therapeutic dose. Typically, ionic lithium is prescribed at 0.5 – 1mg. Harari F, Åkesson A, Casimiro E, Lu Y, Vahter M (2016) Exposure to lithium through drinking water and calcium homeostasis during pregnancy: a longitudinal study. Environ Res 147:1–7 The estimations of daily intake of oral Li are very diverse. It can vary, depending on its availability in the environment and in food products, from several to several thousand micrograms per day [ 23, 42, 43]. As proposed by Schrauzer (2002), the daily requirement for Li is 1000 μg/day for a 70-kg adult (14.3 μg/kg body weight). According to other authors, this is a cautious estimate, not reflecting individual differences that may require even higher consumption to maintain optimal health [ 17]. However, one should bear in mind that Li is not considered officially as a micronutrient; thus, these recommendations are only provisional and cannot formally be used in dietary practice [ 23].