Niacyna B3 w leczeniu

Product Information

Wise A, Foord SM, Fraser NJ, Barnes AA, etal. (March 2003). "Molecular identification of high and low affinity receptors for nicotinic acid". The Journal of Biological Chemistry. 278 (11): 9869–74. doi: 10.1074/jbc.M210695200. PMID 12522134. osoby niedożywione z powodu stosowania nieracjonalnych (bardzo niskokalorycznych lub nieurozmaiconych) diet, USDA National Nutrient Database for Standard Reference, Release 22. Niacin (mg) Content of Selected Foods per Common Measure, sorted by nutrient content, Departament Rolnictwa USA ( ang.). Lai E, De Lepeleire I, Crumley TM, Liu F, Wenning LA, etal. (June 2007). "Suppression of niacin-induced vasodilation with an antagonist to prostaglandin D2 receptor subtype 1". Clinical Pharmacology and Therapeutics. 81 (6): 849–57. doi: 10.1038/sj.clpt.6100180. PMID 17392721. S2CID 2126240. Niacin. Micromedex 2.0 Healthcare Series. http://www.micromedexsolutions.com. Accessed Aug. 9, 2017.

Poziom niacyny jest zwykle badany w moczu [9], gdyż testy te są uznawane za dokładniejsze niż testy krwi [10]. a b c "Nutrient reference values for Australia and New Zealand" (PDF). National Health and Medical Research Council. 9 September 2005. Archived from the original (PDF) on 21 January 2017 . Retrieved 19 June 2018. Wu BJ, Yan L, Charlton F, Witting P, Barter PJ, Rye KA (May 2010). "Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids". Arteriosclerosis, Thrombosis, and Vascular Biology. 30 (5): 968–75. doi: 10.1161/ATVBAHA.109.201129. PMID 20167660. Niacyna jest istotna dla zdrowia naszego organizmu, dlatego jej niedobór jest szybko sygnalizowany. Które symptomy powinny wzbudzić nasz niepokój?Romani M, Hofer DC, Katsyuba E, Auwerx J (April 2019). "Niacin: an old lipid drug in a new NAD+ dress". J. Lipid Res. 60 (4): 741–6. doi: 10.1194/jlr.S092007. PMC 6446705. PMID 30782960. Małe niedobory niacyny mogą powodować zwolnienie metabolizmu, przez co zmniejszenie tolerancji na zimno.

Redzic, S., Hashmi, M. F., & Gupta, V. (2022). Niacin Deficiency. W StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK557728/ Rola niacyny w wytwarzaniu energii i właściwościach przeciwutleniających/przeciwzapalnych skłoniła niektórych badaczy do oceny, czy może ona pomóc w zapobieganiu nadciśnieniu. a b c d Ong KL, Barter PJ, Waters DD (April 2014). "Cardiovascular drugs that increase the risk of new-onset diabetes". Am. Heart J. 167 (4): 421–8. doi: 10.1016/j.ahj.2013.12.025. PMID 24655688. S2CID 205306912. Archived from the original on 28 June 2020 . Retrieved 27 June 2020. Alcohol. Taking niacin with alcohol might increase the risk of liver damage and worsen niacin side effects, such as flushing and itching. Domanico D, Verboschi F, Altimari S, Zompatori L, Vingolo EM (2015). "Ocular Effects of Niacin: A Review of the Literature". Med Hypothesis Discov Innov Ophthalmol. 4 (2): 64–71. PMC 4458328. PMID 26060832.

Extended release niacin was combined with lovastatin (Advicor), and with simvastatin (Simcor), as prescription drug combinations. The combination niacin/lovastatin was approved by the U.S. Food and Drug Administration (FDA) in 2001. [57] The combination niacin/simvastatin was approved by the FDA in 2008. [58] [59] Subsequently, large outcome trials using these niacin and statin therapies were unable to demonstrate incremental benefit of niacin beyond statin therapy alone. [60] The FDA withdrew approval of both drugs in 2016. The reason given: "Based on the collective evidence from several large cardiovascular outcome trials, the Agency has concluded that the totality of the scientific evidence no longer supports the conclusion that a drug-induced reduction in triglyceride levels and/or increase in HDL-cholesterol levels in statin-treated patients results in a reduction in the risk of cardiovascular events." The drug company discontinued the drugs. [61] Contraindications [ edit ]

a b c "Overview on Dietary Reference Values for the EU population as derived by the EFSA Panel on Dietetic Products, Nutrition and Allergies" (PDF). 2017. Archived (PDF) from the original on 28 August 2017 . Retrieved 31 August 2017. Activating HCA 2 has effects other than lowering serum cholesterol and triglyceride concentrations: antioxidative, anti-inflammatory, antithrombotic, improved endothelial function and plaque stability, all of which counter development and progression of atherosclerosis. [73] [74] Niacyna, zwana także witaminą B3 lub witaminą PP, należy do witamin z grupy B rozpuszczalnych w wodzie. Malik S, Kashyap ML (November 2003). "Niacin, lipids, and heart disease". Curr Cardiol Rep. 5 (6): 470–6. doi: 10.1007/s11886-003-0109-x. PMID 14558989. S2CID 27918392.

Side Effects

Both the DRI and DRV describe amounts needed as niacin equivalents (NE), calculated as 1mg NE = 1mg niacin or 60mg of the essential amino acid tryptophan. This is because the amino acid is utilized to synthesize the vitamin. [4] [21]

Metaanaliza 11 kontrolowanych badań klinicznych przeprowadzona w 2009 roku wykazała, iż niacyna, użyta jako jedyny lek lub też w kombinacji z innymi lekami, znacznie zmniejszyła ilość głównych incydentow chorób wieńcowych (zawałów, udarów mózgu) oraz rozwój miażdżycy [30].Yet it was just one study showing that one form of vitamin B 3 could reduce the rate of one type of skin cancer; it didn’t preclude the possibility that some B vitamins could worsen at least some types of cancers. a b c d Keith K. Parker Keith K. i inni, Goodman & Gilman’s the pharmacological basis of therapeutics, New York: McGraw-Hill, 2006, ISBN 0-07-142280-3 . brak strony (książka) Cox M, Lehninger AL, Nelson DR (2000). Lehninger principles of biochemistry. New York: Worth Publishers. ISBN 978-1-57259-153-0. a b c Hegyi J, Schwartz RA, Hegyi V (January 2004). "Pellagra: dermatitis, dementia, and diarrhea". International Journal of Dermatology. 43 (1): 1–5. doi: 10.1111/j.1365-4632.2004.01959.x. PMID 14693013. S2CID 33877664. Niacin in medicinal doses can cause modest elevations in serum transaminase and unconjugated bilirubin, both biomarkers of liver injury. The increases usually resolve even when drug intake is continued. [15] [70] [71] However, less commonly, the sustained release form of the drug can lead to serious hepatotoxicity, with onset in days to weeks. Early symptoms of serious liver damage include nausea, vomiting and abdominal pain, followed by jaundice and pruritus. The mechanism is thought to be a direct toxicity of elevated serum niacin. Lowering dose or switching to the immediate release form can resolve symptoms. In rare instances the injury is severe, and progresses to liver failure. [15] Diabetes [ edit ]