Cabergoline for men & women: Dostinex (Know Your Medicine)

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It’s considered safe to take dopamine agonists for long periods, even for several years (Melmed et al 2011, Hartree 2012). Do dopamine agonists have any side-effects?Common side-effects of bromocriptine and cabergoline include: There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you. BabyCentre's editorial team is committed to providing the most helpful and trustworthy pregnancy and parenting information in the world. When creating and updating content, we rely on credible sources: respected health organisations, professional groups of doctors and other experts, and published studies in peer-reviewed journals. We believe you should always know the source of the information you're seeing. Learn more about our editorial and medical review policies. You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you. You may also be prescribed dopamine agonists if you’re having IVF and you’re at risk of ovarian hyper-stimulation syndrome (OHSS) (HFEA 2015). Cabergoline is currently recommended for this as it is an effective treatment that won't affect your chance of pregnancy or increase your risk of multiple pregnancy (NICE 2015). How long will fertility treatment with dopamine agonists last?Your exact dosage will depend on your particular fertility problem and which drug you’ve been prescribed. You’ll be under the care of a specialist doctor, who may increase your dose slowly whether you are taking cabergoline or bromocriptine (BNF 2016).

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What are dopamine agonists?Dopamine agonists are fertility drugs that can help you to conceive if you are experiencing problems with ovulation. Cabergoline and bromocriptine are most commonly used for this purpose. They are used to correct a hormonal imbalance that can prevent your ovaries from releasing an egg every month. They work by stimulating the dopamine receptors in your brain (BNF 2016, NICE 2013) and suppressing the release of prolactin from your pituitary gland (BNF 2016). For people with high blood pressure from pregnancy: If you’re currently pregnant and have high blood pressure from your pregnancy, you should not use this drug. It can make your condition worse. Cabergoline is a long-acting medication, usually taken once or twice a week. Cabergoline can make you feel a bit dizzy, or cause nausea or headaches. Side-effects may be reduced if you take the cabergoline with food, or last thing at night before going to bed. Usually your specialist will recommend a low starting dose to reduce the risk of side-effects, gradually increasing the dose if necessary as your body gets used to the medication. Rare side-effects of cabergoline Cabergoline is a medicine used to treat hyperprolactinemia, a condition portrayed by significant levels of prolactin, this is why it is used within the treatment of IVF to allow the reduction in prolactin levels, as too much prolactin can affect the ovulation process and thus, cause infertility issues. Once you have reduced the prolactin levels within your body this will help to start the ovulation process.

Cabergoline can be taken along-side Clomiphene within your treatment for infertility. This can have the added benefit of, not only starting to be able to ovulate, but also lowering the risk of having multiple eggs fertilised at once. This means that you will not run the risk of having twins or triplets while trying to conceive a baby. Cabergoline Uses and Dosage This medication has not been studied in children. It should not be used in people younger than 18 years. Your doctor may start you on a lowered dosage or a different treatment schedule. This can help keep levels of this drug from building up too much in your body. If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room. Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death). Warnings for people with certain health conditions For people with heart problems: If you have uncontrolled high blood pressure or heart valve problems, you should not use this drug. It can make your condition worse. If you have high blood pressure, ask your doctor if your blood pressure is under control.

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Cabergoline oral tablet can cause drowsiness as well as other side effects. More common side effectsIf you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

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You should inform your doctor about any side effects which occur. Serious reactions are possible, and immediate medical attention is required should this happen. Examples include unusual changes in vision, pain in the groin, lumps noticeable around the stomach, reduced urination and coughing. This list is complete, and it is possible that some reactions which have not been listed here may occur.Also very rarely, cabergoline can cause psychiatric disturbances or abnormally impulsive behaviour, for example a strong desire to gamble or a greatly increased sex drive. It is worth letting your ‘nearest and dearest’ know about this, just in case they notice any changes of this sort. If you are concerned you should consult your GP or your endocrinologist. These problems usually settle when the treatment is stopped. How is the response to cabergoline treatment monitored? Cabergoline is used to treat hyperprolactinemia (high levels of prolactin in your body). This happens when your pituitary gland makes extra prolactin. High prolactin levels may be caused by a hormone problem or by a tumor in your pituitary gland. Cabergoline is commonly sold under the name Dostinex. Because certain steroids can raise prolactin levels, a lot of people who are sensitive to prolactin can run the risk of gynecomastia. Running Cabergoline prevents this from occurring. It’s also popular to use because it will fight off erectile dysfunction and a decreased libido. Seek immediate emergency medical attention if you suffer an allergic reaction. Symptoms to watch for, which may be indicative of a reaction, include skin rashes, hives, swelling of the face or limbs, trouble breathing, and trouble swallowing. You should not take cabergoline with erythromycin or clarithromycin (these are types of antibiotics), as they increase the cabergoline level in the blood, increasing the risk of sideeffects. You should also avoid domperidone and metoclopramide (sometimes used to treat nausea or vomiting), as they counter-act the effect of the cabergoline. Are there alternatives to cabergoline treatment?