The Renal Drug Handbook, 3rd Edition

Product Information

The following details the structure of the monographs found within The Renal Drug Database. Where appropriate, supporting information is provided. It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management. Summary of Product Characteristics: Terbinafine 250 mg tablets. Kent Pharmaceuticals UK Ltd. Revised March 2016. Oropharyngeal and oesophageal candidiasis in HIV positive patients at risk of relapse: 100mg to 200mg daily or 200mg three times weekly. Treatment is indefinite in patients with chronic immune suppression.

Summary of Product Characteristics: Spironolactone Tablets 25mg. Actavis UK Ltd. Revised June 2014. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 9th edition (2011) ed. Briggs, G., Freeman, R. and Yaffe, S. Lippincott Williams & Wilkins, Philadelphia.The manufacturer recommends a washout period of around 1 week after a single-dose or discontinuation of a course of treatment before becoming pregnant. Pregnancy and Lactation Pregnancy The following texts have been used as reference sources for the compilation of The Renal Drug Database: Administration: Information is given on reconstitution, route and rate of administration, and other relevant factors. Much of the information relates to local practice, including information on the minimum volume that drugs can be added to. Only the most commonly used and compatible reconstitution and dilution solutions are stated. The product literature should always be consulted for the most up to date information. Summary of Product Characteristics: Quinine Sulfate Tablets 300mg. Actavis UK Ltd. Revised April 2013. Physicochemical Principles of Pharmacy in Manufacture, Formulation and Clinical Use - 6th ed. (2016)

the kidney function expressed as estimated glomerular filtration rate (eGFR) normalised to a body surface area of 1.73m 2Advise patient about responsibility for understanding and following directions with regards to administration, monitoring and care.

Summary of Product Characteristics: Spironolactone Film-coated Tablets 12.5mg. ADVANZ Pharma. Revised October 2020. The Renal Drug Database is not intended to offer definitive advice or guidance on how drugs should be used in patients with renal impairment, nor is it a comprehensive and complete list of all drugs licensed in the UK. Quinine should be used with caution in patients with atrial fibrillation or other serious heart disease as it may cause hypoprothrombinaemia. Patients and or parents or the legal responsible person must be able to follow directions regarding the administration of this medicinal product, their monitoring and care. Pregnancy and Lactation Pregnancy Although the effects on the breastfeeding infant are unknown, the safe use of fluconazole in infants has been documented. Side EffectsAfter diagnosis of hyperaldosteronism has been established by more definitive testing, spironolactone may be administered at doses of 100mg to 400mg daily in preparation for surgery. For patients who are unsuitable for surgery spironolactone may be employed for long term maintenance therapy at the lowest effective dosage for the individual patient. Launched in 2014, The Renal Drug Database comprises all monograph information from the highly successful The Renal Drug Handbook, the universally-trusted resource for pharmacists seeking definitive prescribing information when treating patients with renal impairment. Other information: Details given here are only relevant to the use of that particular drug in patients with impaired renal function or on renal replacement therapy. For more general information, please refer to the Summary of Product Characteristics for that drug.

It is strongly recommended that all users read carefully the following information prior to using The Renal Drug Database. Exfoliative cutaneous reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported rarely. If a rash develops in a patient treated for a superficial fungal infection which may be attributed to fluconazole, discontinue treatment. If patients with invasive/systemic fungal infections develop rashes, they should be closely monitored and fluconazole discontinued if bullous lesions or erythema multiforme develop. Coccidioidomycosis: 200mg to 400mg daily. Treatment is for eleven months but can be increased to longer than twenty four months. 800mg daily may be necessary for some infections and in particular for meningeal disease. Treatment given for seven to fourteen days in oropharyngeal candidiasis (longer if required in severely immunocompromised patients).

One of our top member benefits!

If urinary Na+/K+ ratio is greater than 1, give 100mg daily. If the ratio is less than 1, give 200mg to 400mg daily. Summary of Product Characteristics: Diflucan 10 mg/ml powder for oral suspension. Pfizer Ltd. Revised May 2022. The Preface outlines how to use the monographs and basic drug dosing advice including valuable information on the use of estimated glomerular filtration rate (eGFR). Dose in renal impairment: The level of renal function below which the dose of a drug must be reduced depends largely on the extent of renal metabolism and elimination, and on the drug’s toxicity. Most drugs are relatively well tolerated, have a broad therapeutic index or are metabolised and excreted hepatically, so precise dose modification is unnecessary. In such cases, the user is instructed to ‘dose as in normal renal function’.