Bones & Honey: A Heathen Prayer Book

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Yue, W.; Wang, J.-P.; Li, Y.; Fan, P.; Liu, G.; Zhang, N.; Conaway, M.; Wang, H.; Korach, K.S.; Bocchinfuso, W.; et al. Effects of estrogen on breast cancer development: Role of estrogen receptor independent mechanisms. Int. J. Cancer 2010, 127, 1748–1757. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version] Omelka, R.; Martiniakova, M.; Svik, K.; Slovak, L.; Payer, J.; Oppenbergerova, I.; Kovacova, V.; Babikova, M.; Soltesova-Prnova, M. The effects of eggshell calcium (Biomin H ®) and its combinations with alfacalcidol (1α-hydroxyvitamin D3) and menaquinone-7 (vitamin K2) on ovariectomy-induced bone loss in a rat model of osteoporosis. J. Anim. Physiol. Anim. Nutr. 2021, 105, 336–344. [ Google Scholar] [ CrossRef]

Mosavat et al. investigated the effects of high and low-intensity jumping exercise combined with honey on bone and gonadotrophins [ 94]. The low-intensity jumping exercise was defined as 20 jumps per day for five days/week for eight weeks, while the high-intensity jumping exercise was defined as 80 jumps per day for five days/week for eight weeks. The results showed that honey supplementation combined with high-intensity exercise invokes a greater increase in the tibial and femoral mass, serum total calcium, and alkaline phosphatase (ALP) levels. The hormonal changes were not observed in the combined honey and exercise groups. Serum luteinizing hormone concentrations were significantly greater in honey combined with the low- and high-intensity exercise group compared with the high-intensity exercise-alone group [ 94]. Mosavat et al. further evaluated the stress hormones and showed that the serum cortisol level was higher, while the serum progesterone level was lower in the group undergoing low- and high-intensity exercise alone compared with the control group [ 94]. In contrast, the combined honey plus exercise group had significantly lower serum cortisol and higher serum progesterone levels compared with the exercise alone group, which signifies the role of honey in regulating hormonal balance required for normal bone remodelling. For the reproductive system in these rats, the relative weight of the excised uterus was significantly greater in the honey plus low-intensity exercise group compared to the control group, indicating that it may have oestrogenic properties [ 95]. 5. Human Study 5.1. Effects of Honey versus Hormonal Replacement Therapy Milk & Honey London, Soho's Poland Street, with its blank purple façade, will cease to exist on 26th September 2020. It's been there 18 years, which is a decent enough run for any bar these days, and it certainly isn't the first or the last casualty of a global pandemic. But during its lengthy tenure it became a barometer for bartender training and education which few other venues came close to. Pierre Marie-Bisson will be Milk & Honey's last GM. He has been in the role for five years, lived in England's capital for seven, and once the venue closes, he'll be leaving London for good. "It's a weird feeling," he tells me. "I've helped open places, but never closed one. You always go into bars thinking what you can learn and take from them, and what you can bring to make it better, the little stone you add to the building, and normally you leave knowing you're better and the bar is better. Milk & Honey closing is frustrating in a way because some things can still be better, some things are not yet done." Rao, L.G.; Rao, A.V.; Rao, L.G.; Rao, A.V. Oxidative Stress and Antioxidants in the Risk of Osteoporosis—Role of the Antioxidants Lycopene and Polyphenols; IntechOpen: Rijeka, Croatia, 2013; ISBN 978-953-51-1066-8. [ Google Scholar] Age-related chronic inflammation also plays an essential role in the pathogenesis of osteoporosis by influencing bone remodelling [ 14]. In the presence of RANKL, the cytokines TNF- α, interleukins (IL)-6, and IL-1 will cause an excessive formation of osteoclasts while inhibiting osteoblast activities [ 15]. Proinflammatory cytokines like TNF- α also stimulates osteoclast development and increases the production of macrophage colony-stimulating factors (M-CSF) by bone marrow stromal cells (BMSCs) [ 16, 17]. They also suppress osteoblasts from releasing the RANKL decoy receptor, osteoprotegerin (OPG). This decoy primarily prevents the binding of RANKL with its corresponding receptor to stimulate osteoclastogenesis [ 15].Yang, C.; Gong, G.; Jin, E.; Han, X.; Zhuo, Y.; Yang, S.; Song, B.; Zhang, Y.; Piao, C. Topical application of honey in the management of chemo/radiotherapy-induced oral mucositis: A systematic review and network meta-analysis. Int. J. Nurs. Stud. 2019, 89, 80–87. [ Google Scholar] [ CrossRef] [ PubMed] Pfeiler, G.; Königsberg, R.; Hadji, P.; Fitzal, F.; Maroske, M.; Dressel-Ban, G.; Zellinger, J.; Exner, R.; Seifert, M.; Singer, C.; et al. Impact of body mass index on estradiol depletion by aromatase inhibitors in postmenopausal women with early breast cancer. Br. J. Cancer 2013, 109, 1522–1527. [ Google Scholar] [ CrossRef][ Green Version]

Moreira, A.J.; Ordoñez, R.; Cerski, C.T.; Picada, J.N.; García-Palomo, A.; Marroni, N.P.; Mauriz, J.L.; González-Gallego, J. Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. PLoS ONE 2015, 10, e0144517. [ Google Scholar] [ CrossRef] [ PubMed] Afroz, R.; Tanvir, E.M.; Paul, S.; Bhoumik, N.C.; Gan, S.H.; Khalil, M.I. DNA Damage Inhibition Properties of Sundarban Honey and its Phenolic Composition. J. Food Biochem. 2016, 40, 436–445. [ Google Scholar] [ CrossRef] Several artists have covered “Honey Bones,” paying homage to its enchanting melodies and timeless lyrics. These covers often interpret the song in unique ways, adding new dimensions to its meaning. 10. How does “Honey Bones” fit into Dope Lemon’s discography?

The rigorous exams, the rewards for expanding knowledge – both monetary and other – and the prestige of Milk & Honey on your CV have yet to be matched. This was where some of the finest in the drinks industry cut their teeth, and in one and a half months of writing this will be its final curtain call. If you have osteoarthritis, you could try the apple cider vinegar + honey combination. The vinegar is a pretty strong antioxidant, so it could help you a lot, especially if you’re older.