livasia Asian Opium Table, Red, Glass Mosaic Style, Handmade Thai Furniture, Different Sizes (Large)

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Smoking of opium came on the heels of tobacco smoking and may have been encouraged by a brief ban on the smoking of tobacco by the Ming emperor. The prohibition ended in 1644 with the coming of the Qing dynasty, which encouraged smokers to mix in increasing amounts of opium. [1] In 1705, Wang Shizhen wrote, "nowadays, from nobility and gentlemen down to slaves and women, all are addicted to tobacco." Tobacco in that time was frequently mixed with other herbs (this continues with clove cigarettes to the modern day), and opium was one component in the mixture. Tobacco mixed with opium was called madak (or madat) and became popular throughout China and its seafaring trade partners (such as Taiwan, Java, and the Philippines) in the 17th century. [47] In 1712, Engelbert Kaempfer described addiction to madak: "No commodity throughout the Indies is retailed with greater profit by the Batavians than opium, which [its] users cannot do without, nor can they come by it except it be brought by the ships of the Batavians from Bengal and Coromandel." [20] Though opium yields vary based on growing conditions, 2.5 acres (1 hectare) of poppies typically produce between 17.6 and 33 lbs. (8 to 15 kilograms) of raw opium, according to the book " Opium: A History" (St. Martin's Griffin, 1999). Estimated yields of heroin from raw opium are between 6 percent and 10 percent. Thus, the acre of poppies found in North Carolina would yield a little more than 13 lbs. (6 kg) of raw opium and 1.3 lbs. (0.6 kg) of heroin in a full growing season in the best of circumstances. Baumler 2001, p.1-2: "Although many of the specific techniques they used were similar to those of the Nationalists, the Communist anti-opium campaigns were carried out in the context of the successful effort to use mass campaigns to bring all aspects of local life under control, and thus the Communists were considerably more successful than were the Nationalists. Opium and drug use would not be a problem again in China until the post-Mao era." Pseudo-Apuleius: Papaver". Archived from the original on September 28, 2007 . Retrieved June 15, 2007.

Baumler, Alan (2007). The Chinese and Opium under the Republic: Worse Than Floods and Wild Beasts. Albany: State University of New York Press. ISBN 978-0791469538. Opium contains two main groups of alkaloids. Phenanthrenes such as morphine, codeine, and thebaine are the main psychoactive constituents. [153] Isoquinolines such as papaverine and noscapine have no significant central nervous system effects. Morphine is the most prevalent and important alkaloid in opium, consisting of 10–16 percent of the total, and is responsible for most of its harmful effects such as lung edema, respiratory difficulties, coma, or cardiac or respiratory collapse. Morphine binds to and activates mu opioid receptors in the brain, spinal cord, stomach and intestine. Regular use can lead to drug tolerance or physical dependence. Chronic opium addicts in 1906 China [48] consumed an average of eight grams of opium daily; opium addicts in modern Iran [154] are thought to consume about the same. Professor Arthur C. Gibson. "The Pernicious Opium Poppy". University of California, Los Angeles. Archived from the original on October 20, 2013 . Retrieved February 22, 2014.

Poppy seeds and drug testing

a b c d e f g h i j Paul L. Schiff Jr. (2002). "Opium and its alkaloids". American Journal of Pharmaceutical Education. Archived from the original on October 21, 2007 . Retrieved May 8, 2007. The addictive character of opium is related to the binding to the μ-opioid receptors, which will activate dopaminergic neurons in the ventral tegmental area of the midbrain and thus, enhance the dopamine release in the nucleus accumbens. This mechanism involves the reward activity of the mesolimbic dopaminergic pathway. 10 Target Opium contains 50 different alkaloid opiates. The most common metabolism of opiates is to be ultimately converted to morphine which is further converted to morphine-3,6-diglucuronide. 16 Opioids are metabolized vastly by the enzyme CYP 2D6 and any mutation in this kind of enzyme or coadministration with drugs that interfere with this enzyme may generate a change in the metabolism speed. 18 For years, because of this metabolism pathway, it was very hard to differentiate between illicit heroin users and involuntary exposure to poppy seeds. The original tests for this differentiations were based in the presence of morphine in urine without evidence of 6-monoacetylmorphine. Now it is known the presence of a glucuronide metabolite only in the consumption of heroin called ATM4G and this allows a clear differentiation of the consumption of illegal heroin and poppy seed ingestion. 6 The earliest clear description of the use of opium as a recreational drug in China came from Xu Boling, who wrote in 1483 that opium was "mainly used to aid masculinity, strengthen sperm and regain vigor", and that it "enhances the art of alchemists, sex and court ladies". He also described an expedition sent by the Ming dynasty Chenghua Emperor in 1483 to procure opium for a price "equal to that of gold" in Hainan, Fujian, Zhejiang, Sichuan and Shaanxi, where it is close to the western lands of Xiyu. A century later, Li Shizhen listed standard medical uses of opium in his renowned Compendium of Materia Medica (1578), but also wrote that "lay people use it for the art of sex," in particular the ability to "arrest seminal emission". This association of opium with sex continued in China until the end of the 19th century.

The risk or severity of adverse effects can be increased when Opium is combined with 1,2-Benzodiazepine. The Chinese Diaspora in the West (1800s to 1949) first began to flourish during the 19th century due to famine and political upheaval, as well as rumors of wealth to be had outside of Southeast Asia. Chinese emigrants to cities such as San Francisco, London, and New York City brought with them the Chinese manner of opium smoking, and the social traditions of the opium den. [50] [51] The Indian Diaspora distributed opium-eaters in the same way, and both social groups survived as " lascars" (seamen) and " coolies" (manual laborers). French sailors provided another major group of opium smokers, having gotten the habit while in French Indochina, where the drug was promoted and monopolized by the colonial government as a source of revenue. [52] [53] Among white Europeans, opium was more frequently consumed as laudanum or in patent medicines. Britain's All-India Opium Act of 1878 formalized ethnic restrictions on the use of opium, limiting recreational opium sales to registered Indian opium-eaters and Chinese opium-smokers only and prohibiting its sale to workers from Burma. [54] Likewise, in San Francisco, Chinese immigrants were permitted to smoke opium, so long as they refrained from doing so in the presence of whites. [50] a b Aurin, Marcus (January 1, 2000). "Chasing the Dragon: The Cultural Metamorphosis of Opium in the United States, 1825–1935". Medical Anthropology Quarterly. 14 (3): 414–441. doi: 10.1525/maq.2000.14.3.414. JSTOR 649506. PMID 11036586. Somogyi AA, Larsen M, Abadi RM, Jittiwutikarn J, Ali R, White JM: Flexible dosing of tincture of opium in the management of opioid withdrawal: pharmacokinetics and pharmacodynamics. Br J Clin Pharmacol. 2008 Nov;66(5):640-7. doi: 10.1111/j.1365-2125.2008.03277.x. [ Article] Opium prohibition in China began in 1729, yet was followed by nearly two centuries of increasing opium use. A massive destruction of opium by an emissary of the Chinese Daoguang Emperor in an attempt to stop opium smuggling by the British led to the First Opium War (1839–1842), in which Britain defeated China. After 1860, opium use continued to increase with widespread domestic production in China. By 1905, an estimated 25 percent of the male population were regular consumers of the drug. Recreational use of opium elsewhere in the world remained rare into late in the 19th century, as indicated by ambivalent reports of opium usage. [44] In 1906, 41,000 tons were produced, but because 39,000 tons of that year's opium were consumed in China, overall usage in the rest of the world was much lower. [48] These figures from 1906 have been criticized as overestimates. [49] A Chinese opium house; photographed in 1902a b c d e f g Dikotter, Frank (2004). Narcotic Culture: A History of Drugs in China. Hurst. p.3. ISBN 978-0226149059. United States Congress Senate Committee on the Judiciary. Communist china and illicit narcotic traffic. 1955年: United States Government Printing Office. OCLC 6466332. {{ cite book}}: CS1 maint: location ( link) a b Kramer John C (1979). "Opium Rampant: Medical Use, Misuse and Abuse in Britain and the West in the 17th and 18th Centuries". British Journal of Addiction. 74 (4): 377–389. doi: 10.1111/j.1360-0443.1979.tb01367.x. PMID 396938. In Eastern culture, opium is more commonly used in the form of paregoric to treat diarrhea. This is a weaker solution than laudanum, an alcoholic tincture which was prevalently used as a pain medication and sleeping aid. Tincture of opium has been prescribed for, among other things, severe diarrhea. [151] Taken thirty minutes prior to meals, it significantly slows intestinal motility, giving the intestines greater time to absorb fluid in the stool. a b Hevia, James Louis (2003). "Opium, Empire, and Modern History" (PDF). China Review International. 10 (2): 307–326. doi: 10.1353/cri.2004.0076. ISSN 1527-9367. S2CID 143635262.

Most illicit heroin is sold as a white or brownish powder and may be "cut" with other substances such as sugar, starch, powdered milk, or quinine. It can also be cut with strychnine or other poisons. The treaties with the British soon led to similar arrangements with the United States and France. These later became known as the Unequal Treaties, while the Opium Wars, according to Chinese historians, represented the start of China's " Century of humiliation".Presley CC, Lindsley CW. DARK Classics in Chemical Neuroscience: opium, a historical perspective. ACS Chemical Neuroscience. 2018;9(10):2503-18. Oral ingestion does not usually lead to a "rush", but use of heroin in suppository form may have intense euphoric effects. Lee S, Park Y, Han E, Choi H, Chung H, Oh SM, Chung KH: Thebaine in hair as a marker for chronic use of illegal opium poppy substances. Forensic Sci Int. 2011 Jan 30;204(1-3):115-8. doi: 10.1016/j.forsciint.2010.05.013. Epub 2010 Jun 16. [ Article] Eventually, laudanum became readily available and extensively used by the 18th century in Europe, especially England. [33] Compared to other chemicals available to 18th century regular physicians, opium was a benign alternative to arsenic, mercury, or emetics, and it was remarkably successful in alleviating a wide range of ailments. Due to the constipation often produced by the consumption of opium, it was one of the most effective treatments for cholera, dysentery, and diarrhea. As a cough suppressant, opium was used to treat bronchitis, tuberculosis, and other respiratory illnesses. Opium was additionally prescribed for rheumatism and insomnia. [34] Medical textbooks even recommended its use by people in good health, to "optimize the internal equilibrium of the human body". [19]

Hanes, W. Travis; Sanello, Frank (2002). Opium Wars: The Addiction of One Empire and the Corruption of Another. Sourcebooks. ISBN 9781402201493. . popular history.Opium has a harm. Opium is a poison, undermining our good customs and morality. Its use is prohibited by law. Now the commoner, Yang, dares to bring it into the Forbidden City. Indeed, he flouts the law! P. E. Caquet, “Notions of Addiction in the Time of the First Opium War.” The Historical Journal 58, no. 4 (2015): 1009–29. doi:10.1017/S0018246X14000739. Despite drastic penalties and continued prohibition of opium until 1860, opium smuggling rose steadily from 200 chests per year under the Yongzheng Emperor to 1,000 under the Qianlong Emperor, 4,000 under the Jiaqing Emperor, and 30,000 under the Daoguang Emperor. [61] The illegal sale of opium became one of the world's most valuable single commodity trades and has been called "the most long continued and systematic international crime of modern times". [62] Opium smuggling provided 15 to 20 percent of the British Empire's revenue and simultaneously caused scarcity of silver in China. [63]