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NALP3: a key player in caspase-1 activation. J Endotoxin Res. 2006; 12( 4):251–256. doi:10.1177/09680519060120040701 16953978 Adding peanut butter, nuts and seeds such as milled flaxseed to smoothies will help to keep lower and stabilised blood sugar levels. Investigating the long-term effect of CTPI2- and octyl-D-2-HG- treatment on the radiosensitivity of NCI-H460 cells treatment with both, CTPI2 and octyl-D-2-HG, significantly decreased the survival fraction (SF) of NCI-H460 cells in combination with IR-treatment (Fig. 3e). Though CTPI2-treatment was again more effective in reducing the SF of irradiated NCI-H460 cells compared to octyl-D-2-HG treatment (Fig. 3e, f), both treatments increased radiation-induced DNA damage and thus radiosensitized NCI-H460 cells. Octyl-D-2-HG or CTPI2 treatment disrupts mitochondrial metabolism and cellular function In the present study, we explored the role of GAS5 in the inflammation, oxidative stress and pyroptosis of HG-induced HK-2 cells by regulating the expression of miR-452-5p. The results of this experiment showed that GAS5 was downregulated and miR-452-5p was up-regulated obviously in the HG-induced HK-2 cells. miR-452-5p was demonstrated to be a potential target of GAS5. GAS5 overexpression inhibited the inflammation, oxidative stress and pyroptosis of HG-induced HK-2 cells by downregulating the expression of miR-452-5p. Zhan X, Yan C, Chen Y, Wei X, Xiao J, Deng L, Yang Y, Qiu P, Chen Q. Celastrol antagonizes high glucose-evoked podocyte injury, inflammation and insulin resistance by restoring the HO-1-mediated autophagy pathway. Mol Immunol. 2018;104:61–8.

Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Alfred Yung WK, Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150: 685–696, 2012. doi: 10.1016/j.cell.2012.07.018. D-2-Hydroxyglutarate (D-2-HG) Assay Kit (Colorimetric) (BioVision, Milpitas, CA, USA) was applied to quantify the intracellular D-2-HG levels according to the manufacturer’s protocol. In brief, 10 million cells were homogenized, lysed, and spun down. Supernatant was collected and transferred to 96-well plate followed by measuring the enzymatic conversion of D-2-HG to α-KG which could interact with the probe and produce a detectable colored product. Absorbance at 450 nm was measured with a BioTek Synergy H1 Microplate reader (BioTek Instruments, Inc., Winooski, VT, USA). Transfection and treatment Guenther MG, Levine SS, Boyer LA, Jaenisch R, Young RA. A chromatin landmark and transcription initiation at most promoters in human cells. Cell 130: 77–88, 2007. doi: 10.1016/j.cell.2007.05.042.Diabetes is a kind of metabolic and noncommunicable disease, characterized by a continuous increase of blood glucose, and often involves multiple organs. About 30% of diabetic patients will eventually develop into diabetic nephropathy (DN). Citation1 – Citation3 DN not only has a high incidence rate, but also a high mortality rate, which brings great physical and mental pressure and economic burden to individual family and society. Therefore, how to effectively treat DN has become a focusing problem. You should avoid using aggressive cleaning products and also be careful with advice on the internet. For example, Cif, soda or lemon can cause scratches, discolouring and other damage to your hob. You should use only lukewarm water, a damp cloth or a product that was developed specifically for cleaning an induction hob. You can try HG hob cleaner and HG hob cleaner extra strong. Sun G, Reddy MA, Yuan H, Lanting L, Kato M, Natarajan R. Epigenetic histone methylation modulates fibrotic gene expression. J Am Soc Nephrol 21: 2069–2080, 2010. doi: 10.1681/ASN.2010060633.

Any foods which are blended, blitzed, juiced or mashed are more broken down, sometimes with much of the fibre stripped away and so the glucose from them will be absorbed faster than the foods in their natural form and can cause rapid high blood sugars. et al. Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling. J Biol Chem. 2018; 293( 24): jbc.RA118.001723. doi:10.1074/jbc.RA118.001723 Reidy K, Kang HM, Hostetter T, Susztak K. Molecular mechanisms of diabetic kidney disease. J Clin Invest 124: 2333–2340, 2014. doi: 10.1172/JCI72271. To verify our assumption on CTPI2-mediated suppression of HR repair, we additionally quantified Rad51 foci as a marker for DNA repair by HR in A549, NCI-H460, U87-MG, and T98G cells exposed to irradiation with 5 Gy (Figs. 2d; S1e). SLC25A1 inhibition significantly enhanced the number of Rad51 foci when analyzed at 6 h after irradiation and also retarded the resolution of Rad51 foci (Figs. 2d; S1e). The CTPI2-induced impairment of Rad51 foci resolution in irradiated cancer cells corroborate a disturbance of HR repair by SLC25A1 inhibition.El-Osta A, Brasacchio D, Yao D, Pocai A, Jones PL, Roeder RG, Cooper ME, Brownlee M. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med 205: 2409–2417, 2008. doi: 10.1084/jem.20081188. Just after you’ve eaten is the best time to clean an induction hob. Once the hob has cooled down, use a damp cloth to remove any food remnants and stain. This means you can remove any remnants and grease before they solidify and become more difficult to remove. You can then use a clean microfiber cloth for polishing.

Bauer DE, Hatzivassiliou G, Zhao F, Andreadis C, Thompson CB. ATP citrate lyase is an important component of cell growth and transformation. Oncogene 24: 6314–6322, 2005. doi: 10.1038/sj.onc.1208773.

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We performed standard colony formation assays to assess the long-term survival upon treatment as previously described [ 20, 21]. Different cell densities (200, 400, 800, 1600, and 3200 cells per well) were plated in 6-well plates and treated with indicated drug concentrations 24 h later. Radiation was performed 2 h after drug treatment with doses of 2, 5, and 8 Gy separately. Non-irradiated cells were sham irradiated at room temperature for the same period of time as their irradiated counterparts. 8–10 days later, colonies were stained with methanol containing 0.1% (w/v) Coomassie Blue dye and counted manually. Determination of KDM4 activity

cells were plated in 6 well plates 24 h before treatment. Drug treatment was performed for 24 h and nuclear extracts of treated cells were prepared according to the instructions of the manufacturer (ab113474 – Nuclear Extraction Kit, abcam, Cambridge, UK). The, KDM4 activity was determined in nuclear extracts by a fluorescence-based method according to the manufacturer’s instructions (ab113462 –KDM4/JMJD2 Activity Quantification Kit, abcam, Cambridge, UK). Analysis of cell function by flow cytometry Determination of cytoplasmic and mitochondrial reactive oxygen species (ROS), apoptosis and cell death Cooper ME. Pathogenesis, prevention, and treatment of diabetic nephropathy. Lancet 352: 213–219, 1998. doi: 10.1016/S0140-6736(98)01346-4. Heilig CW, Liu Y, England RL, Freytag SO, Gilbert JD, Heilig KO, Zhu M, Concepcion LA, Brosius FC III. d-glucose stimulates mesangial cell GLUT1 expression and basal and IGF-I-sensitive glucose uptake in rat mesangial cells: implications for diabetic nephropathy. Diabetes 46: 1030–1039, 1997. doi: 10.2337/diab.46.6.1030. Hyperemesis gravidarum (or HG) is a medical term for severe nausea and vomiting in pregnancy. HG begins between 4 – 6 weeks of pregnancy. It usually improves by the 21 st week but can make a reappearance at around 32 weeks briefly due to a surge in hormones. For many women it may continue for the entire pregnancy and can be a daily struggle to live through, making the most basic tasks impossible.

It has also been reported that GAS5 can regulate the inflammation, oxidative stress and apoptosis in some diseases. For instance, Wang et al Citation16 indicated that GAS5 interference weakened the apoptosis and inflammatory injury in the mouse model of middle cerebral artery occlusion (MCAO). Chen et al Citation17 found that silencing of GAS5 promoted cell viability, cell cycle and oxidative stress in malignant melanoma (MM) cells. In addition, GAS5 interference increased inflammation and reduced pyroptosis, thereby promoting the proliferation of ovarian cancer cells and reducing apoptosis. Citation13 Therefore, the expression of GAS5 was various in different diseases, and changing the expression of GAS5 could alleviate or deteriorate the progression of diseases. The present study indicated that GAS5 overexpression could alleviate the inflammation, oxidative stress and pyroptosis of HG-induced HK-2 cells.