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As with all supplements, we recommend that they are taken under the supervision of a doctor or qualified expert, as improper use can cause unwanted side effects. With pregnenolone, this is particularly important, as it has such a key role to play in the day to day function of your body.
Conversion is effected by enzyme availability and concentrations, but also external signals coming from outside the adrenal gland. Think of the HPA Axis and because many steroids such as DHEA are neuro-active, meaning they will activate or inhibit neurotransmitter systems and vice versa, its not just about the usage but also our emotional wellbeing, etc. . Aumenta el crecimiento de las neuronas y mejora la mielización (Capa de grasa que aísla eléctricamente a los nervios)
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Although reports of serious problems are infrequent, the long-term safety of using DHEA regularly for many years is unknown. Effects on risk of cancers for example – especially those of the prostate gland, thyroid, breast and ovaries – are not yet fully understood. Some doctors therefore advise those with a family history of hormone sensitive cancers not to take DHEA. Cai HL, Zhou X, Dougherty GG, et al. Pregnenolone-progesterone-allopregnanolone pathway as a potential therapeutic target in first-episode antipsychotic-naïve patients with schizophrenia. Psychoneuroendocrinol. 2018;90:43-51. doi:10.1016/j.psyneuen.2018.02.004 Pregnenolone inhibits the production of cortisol, which is one of the reasons it is such an effective stress reducer. This has the added benefit of aiding weight loss, as cortisol increases stomach fat. Similarly, by reducing cortisol levels, pregnenolone has the effect of naturally boosting testosterone levels which can increase metabolism and lead to weight loss. Pregnenolone is mainly found in the adrenal glands and brain, but is also present in other tissues such as the liver and skin. Like DHEA, natural levels of pregnenolone peak in the late twenties to early thirties and then start to decline. By the age of 75, a person produces 60% less pregnenolone than in their thirties. National Library of Medicine. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use.
As a supplement, its primary use is in the support of healthy brain function. Pregnenolone is a neuroactive substance found highly concentrated within particular areas of healthy young brains. For this reason, supplemental Pregnenolone has been investigated for its potential to promote sleep quality and cognitive health. For an accurate PSA result, you should NOT have an active urinary infection, ejaculated or exercised heavily in the last 48 hours; had a prostate biopsy in the last 6 weeks or had a DRE (digital rectal examination) in the last week.Please note that this test is sent to a referral lab for processing and results can take up to 10 working days to arrive. Special Instructions: Pregnenolone tests are blood tests conducted on infants, usually as part of a panel of tests. It is used as a diagnostic tool to help find the underlying cause of CAH in infants. CAH is suspected when an infant has ambiguous external sex organs, signs of adrenal insufficiency, excess loss of sodium and fluids, or low or high blood pressure. Purpose of the test
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