Enterogermina 2 Billion (10 Vials)

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Erythromycin resistance was identified by subjecting the erm(34) gene sequence (GenBank Identifier: AY234334) of B. clausii DSM8716 to BLASTn against all Bacillus genomes. This gene was identified in B. clausii ENTPro named as “SSU rRNA (adenine (1518)-N (6)/adenine (1519)-N (6))-dimethyltransferase” (GenBank Identifier: ALA53582). The gene was also identified in all the B. clausii genomes. The gene sequence shared 61% identity to rRNA adenine methyltransferase of B. halodurans and 57% identity to rRNA adenine methyltransferase of B. licheniformis, B. anthracis, B. sonorensis and B. fordii. The rRNA adenine methyltransferase gene from other Bacillus spp. shared 20–50% identity with erm(34) gene. The result reveals that the erm(34) gene is unique to B. clausii and is not present in other members of the Bacillus genus.

Fu X, Adams Z, Liu R, Hepowit NL, Wu Y, Bowmann CF, et al. Methionine Sulfoxide Reductase a (MsrA) and its function in ubiquitin-like protein modification in Archaea. MBio. 2017;8. https://doi.org/10.1128/mBio.01169-17. Stamatakis A. RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics. 2014;30:1312–3. https://doi.org/10.1093/bioinformatics/btu033. Zhang S, Hu Y, Fan Q, Wang X, He J. Two-component system YvqEC-dependent bacterial resistance against vancomycin in Bacillus thuringiensis. Antonie Van Leeuwenhoek. 2015;108:365–76. https://doi.org/10.1007/s10482-015-0489-0. Butyrate is an SCFA that is often associated with positive health outcomes. It is the primary energy source of intestinal epithelial cells, and it affects gut motility, regulates gut endocrine functions, promotes gut epithelial barrier functions by reducing epithelial permeability, and improves gut immune responses [ 33]. The increase in butyrate levels with probiotic treatment may indicate that the probiotic alters the gut microbiome environment in a way that potentially benefits the overall gastrointestinal health of the host. Porwal S, Lal S, Cheema S, Kalia VC. Phylogeny in aid of the present and novel microbial lineages: diversity in Bacillus. PLoS One. 2009;4:e4438. https://doi.org/10.1371/journal.pone.0004438.

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Cotter PD, Hill C. Surviving the acid test: responses of gram-positive bacteria to low pH. Microbiol Mol Biol Rev. 2003;67:429–53, table of contents. https://doi.org/10.1128/MMBR.67.3.429-453.2003.

Some of the spore-forming strains of Bacillus probiotics are marketed commercially as they survive harsh gastrointestinal conditions and bestow health benefits to the host. Results Cotter PD, Hill C, Ross RP. What’s in a name? Class distinction for bacteriocins - Author reply. Nat Rev Microbiol. 2006;4. https://doi.org/10.1038/nrmicro1273-c2. Enterogermina is manufactured as a suspension or as a capsule. The active ingredient in Enterogermina is: Substitute drugs that contain the same active ingredient in the same strength and function as Enterogermina include:

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B. clausii ENTPro proteome was scanned using Hidden Markov Model (HMM) [ 92, 93] for the presence of specific domains involved in acid tolerance, adhesion, antibiotic resistance, antimicrobial production, heavy metal resistance, bile resistance, oxidative and universal stress resistance, and riboflavin synthesis. Identification of antibiotic resistance genes

For qPCR analyses, three technical replicates from each biological replicate were used. Biological replicates were independent sampling points that represented biologically meaningful variation, whereas technical replicates came from a single sample and represented the precision of experimental techniques. Presence of a novel plasmid sequence in B. clausii ENTPro could be a possible source of antibiotic-resistance gene transfer but we could not identify any potential antibiotic-resistance domain(s) in the plasmid. We also searched for the presence of antibiotic resistance genes and efflux pumps in the genomes with multiple methods to avoid false positives.Floch MH, Walker WA. Probiotics are considered nutritional supplements. J Clin Gastroenterol. 2011;45(Suppl):S107. https://doi.org/10.1097/MCG.0b013e3182317e74.