Optibac Probiotics Bifido & Fibre - Vegan Digestive Probiotic Supplement with FOS Fibre to Maintain Regularity & 25 Billion Bacterial Cultures - 30 Sachets

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Altmann F, et al. (2016), 'Genome Analysis of Characterisation of the Exopolysaccharide Produced by Bifidobacterium longum subsp.longum35624TM. Seleem MN, ed. PLoS ONE. 11(9):E0162983 Research is conflicting, inconsistent, or weak for using B. bifidum to treat the following conditions: Doron, S., &Snydman, D. R. (2015). Risk and safety of probiotics. ClinicalInfectious Diseases, 60(s2), S129-S134

Oliveira MN, Bogsan CS, Chinzon D, Eisig JN. Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or decreases the adverse effects of the treatment: a prospective, randomized, double-blind, placebo-controlled study. BMC Gastroenterol. 2013 26;13:56. View abstract. Totsu S, Yamasaki C, Terahara M, Uchiyama A, Kusuda S; Probiotics Study Group in Japan. Bifidobacterium and enteral feeding in preterm infants: cluster-randomized trial. Pediatr Int 2014;56(5):714-9. View abstract. Kondo, J., Xiao, J. Z., Shirahata, A., Baba, M., Abe, A., Ogawa, K., and Shimoda, T. Modulatory effects of Bifidobacterium longum BB536 on defecation in elderly patients receiving enteral feeding. World J Gastroenterol 4-14-2013;19(14):2162-2170. View abstract. Gill, S. R. et al. Metagenomic analysis of the human distal gut microbiome. Science 312, 1355–1359, doi: 10.1126/science.1124234 (2006). Pokusaeva, K., Fitzgerald, G. F. & van Sinderen, D. Carbohydrate metabolism in Bifidobacteria. Genes & nutrition 6, 285–306, doi: 10.1007/s12263-010-0206-6 (2011).Tomasz B, Zoran S, Jaroslaw W, Ryszard M, Marcin G, Robert B, Piotr K, Lukasz K, Jacek P, Piotr G, Przemyslaw P, Michal D. Long-term use of probiotics Lactobacillus and Bifidobacterium has a prophylactic effect on the occurrence and severity of pouchitis: a randomized prospective study. Biomed Res Int. 2014;2014:208064. View abstract. Sibartie S. et al (2009), ‘Modulation of pathogen-induced CCL20 secretion from HT-29 human intestinal epithelial cells by commensal bacteria’, BMC Immunol., 10:54. Xiao, J. Z., Kondo, S., Takahashi, N., Odamaki, T., Iwabuchi, N., Miyaji, K., Iwatsuki, K., and Enomoto, T. Changes in plasma TARC levels during Japanese cedar pollen season and relationships with symptom development. Int.Arch.Allergy Immunol. 2007;144(2):123-127. View abstract.

Xiao, J. Z., Kondo, S., Yanagisawa, N., Takahashi, N., Odamaki, T., Iwabuchi, N., Miyaji, K., Iwatsuki, K., Togashi, H., Enomoto, K., and Enomoto, T. Probiotics in the treatment of Japanese cedar pollinosis: a double-blind placebo-controlled trial. Clin.Exp.Allergy 2006;36(11):1425-1435. View abstract. Lukasik J, Dierikx T, Besseling-van der Vaart I, de Meij T, Szajewska H; Multispecies probiotic in AAD study group. Multispecies probiotic for the prevention of antibiotic-associated diarrhea in children: A randomized clinical trial. JAMA Pediatr 2022;176(9):860-866. View abstract. Chi C, Li C, Buys N, Wang W, Yin C, Sun J. Effects of probiotics in preterm infants: A network meta-analysis. Pediatrics. 2021;147(1):e20200706. View abstract. Von Wright A. et al (2002) ‘The survival and colonic adhesion of Bifidobacterium infantisin patients with ulcerative colitis’, International Dairy Journal, 12:197-200. Xiao, J. Z., Kondo, S., Yanagisawa, N., Miyaji, K., Enomoto, K., Sakoda, T., Iwatsuki, K., and Enomoto, T. Clinical efficacy of probiotic Bifidobacterium longum for the treatment of symptoms of Japanese cedar pollen allergy in subjects evaluated in an environmental exposure unit. Allergol.Int. 2007;56(1):67-75. View abstract.

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A 2011 randomized control trial of 122 people indicates that B. bifidum may help lower symptoms of IBS. In it, researchers provided 62 people a placebo and 60 others a tablet containing B. bifidum each day. After four weeks, about 47 percent of subjects taking the probiotic reported significant relief from symptoms, while only 11 percent of subjects taking the placebo did. Dimidi E, Zdanaviciene A, Christodoulides S, et al. Randomised clinical trial: Bifidobacterium lactis NCC2818 probiotic vs placebo, and impact on gut transit time, symptoms, and gut microbiology in chronic constipation. Aliment Pharmacol Ther. 2019;49(3):251-264. View abstract.