Esoxx One x 14 sachets - Relief for Heartburn, Epigastric Pain, Reflux of Gastric, Epigastric Pain**G

Product Information

Swallow 1 sachet of 10 ml after the main meals and before bedtime, or as recommended by the doctor. Hyaluronic acid, an essential component of epithelia, is a pivotal molecule in the healing process and plays an important role in lubrication, cell differentiation and cell growth We found that the most severe lesions, characterized by erosions involving more than 50% of mucosal area and extending through more than 50% of the epithelial stratified layer, were observed in all the specimens perfused with acid solution for 90 minutes or with acid plus pepsin for 60 minutes. We considered this a suitable and reproducible model to induce a chemical lesion of esophageal mucosa.

Esoxx One not be used in case of hypersensitivity to any component of the formulation. Not recommended for use in pregnant women and lactating mothers.Esoxx One combines the properties of chondroitin, hyaluronic acid and a polymer to adhere, relieve and promote healing of the esophageal mucosa hyaluronic acid, chondroitin sulfate, polyvinylpyrrolidone, C xylitol, sodium benzoate, potassium sorbate, flavors, demineralized water, poloxamer 407. The results showed that Esoxx perfused at 1 mL/minute for 10 minutes, after mucosal damage induction, preventing the penetration of the EB dye in the mucosa and acting as a topical mucosal barrier.

In addition, the ability of the bioadhesive polymer to produce a persistent mucosal barrier effect was also demonstrated after a brief washing of the esophageal mucosa with saline after perfusion with Esoxx. Esoxx ® (Alfa Wassermann, Bologna, Italy) is a new medical device for the topical treatment of the symptoms of gastroesophageal reflux disease (GERD). The product is based on a mixture of hyaluronic acid (HA) and chondroitin sulfate (CS) in a bioadhesive carrier Lutrol ® F 127 (poloxamer 407) (BASF, Milan, Italy), which acts as a buffering agent to form a barrier and to prolong the action on esophageal mucosa. 1 Esoxx One x 14 sachets - Relief for Heartburn, Epigastric Pain, Reflux of Gastric, Epigastric Pain Description:

Hyaluronic acid (hyaluronan; HA) is a glycosaminoglycan made up of glucuronic acid and N-acetylglucosamine disaccharide units. HA is mainly present in the extracellular matrix of soft connective tissues and is involved in several key processes, including cell signaling, wound repair and regeneration, morphogenesis, matrix organization and pathobiology. 2 Clinically, it is largely used for the treatment of several diseases. Topical HA preparations are applied in the management of recurrent aphthous ulceration, with immediate reduction of symptoms due to its barrier effect. 2– 4 Esoxx One is characterised by its protective mucoadhesive effect, prolonging the action of the active substances and promoting healing. It provides rapid and effective relief from the pain of gastroesophageal reflux disease. DOSAGE AND PRECAUTIONS FOR USE OF ESOXX ONE Preparations, mounted with Mowiol ® 4–88 reagent (Calbiochem, Giessen, Germany), were examined by light microscopy; representative photomicrographs were taken using a DS-5M digital camera (Nikon Instruments, Florence, Italy). Sachets Keep out of the reach of children. Keep in a cool, dry place, away from heat sources. Do not freeze.