Lucozade Sport Orange 12x500ml (Packaging May Vary)

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Floegel, A., Pischon, T., Bergmann, M. M., Teucher, B., Kaaks, R., and Boeing, H. Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study. Am J Clin.Nutr. 2012;95(4):901-908. View abstract. Loss of bladder control: Caffeine can make bladder control worse by increasing frequency of urination and the urge to urinate. While the ingredients vary somewhat from one drink to another, those of the Lucozade Original Energy were listed as follows in 2013: carbonated water, glucose syrup (25%), citric acid (E330), lactic acid (E270), flavouring (unspecified), preservatives ( potassium sorbate, sodium bisulphite (E-222)), caffeine, antioxidant ( ascorbic acid), colour ( sunset yellow (E110), Ponceau 4R). After the reformulation to lower sugar in 2017, and another reformulation in 2023, Lucozade Original contains the sweeteners sucralose and acesulfame K. Bolton and Sanford, G. N. Caffeine: Phsychological Effects, Use and Abuse. Othomolecular Psychiatry 1981;10(3):202-211. In another study, 213 caffeine users completed questionnaires after going 16 hours without consuming it. Daily users had greater increases in headaches, fatigue and other withdrawal symptoms than non-daily users ( 32).

Birnbaum, L. J. and Herbst, J. D. Physiologic effects of caffeine on cross-country runners. J.Strength.Cond.Res. 2004;18(3):463-465. View abstract. Bairam, A., Boutroy, M. J., Badonnel, Y., and Vert, P. Theophylline versus caffeine: comparative effects in treatment of idiopathic apnea in the preterm infant. J.Pediatr. 1987;110(4):636-639. View abstract. Arciero, P. J. and Ormsbee, M. J. Relationship of blood pressure, behavioral mood state, and physical activity following caffeine ingestion in younger and older women. Appl Physiol Nutr Metab 2009;34(4):754-762. View abstract. Doyle, L. W., Cheong, J., Hunt, R. W., Lee, K. J., Thompson, D. K., Davis, P. G., Rees, S., Anderson, P. J., and Inder, T. E. Caffeine and brain development in very preterm infants. Ann Neurol. 2010;68(5):734-742. View abstract.Some common MAOIs include phenelzine (Nardil), selegiline (Zelapar), and tranylcypromine (Parnate). Barrington, K. J. and Finer, N. N. A randomized, controlled trial of aminophylline in ventilatory weaning of premature infants. Crit Care Med. 1993;21(6):846-850. View abstract. Common causes of rhabdomyolysis include trauma, infection, drug abuse, muscle strain and bites from poisonous snakes or insects.

Conney, A. H., Kramata, P., Lou, Y. R., and Lu, Y. P. Effect of caffeine on UVB-induced carcinogenesis, apoptosis, and the elimination of UVB-induced patches of p53 mutant epidermal cells in SKH-1 mice. Photochem.Photobiol. 2008;84(2):330-338. View abstract.

A randomized, double-blind comparison of sumatriptan and Cafergot in the acute treatment of migraine. The Multinational Oral Sumatriptan and Cafergot Comparative Study Group. Eur.Neurol. 1991;31(5):314-322. View abstract. Aranda, J. V., Beharry, K., Valencia, G. B., Natarajan, G., and Davis, J. Caffeine impact on neonatal morbidities. J Matern.Fetal Neonatal Med 2010;23 Suppl 3:20-23. View abstract.

Fimland, M. S. and Saeterbakken, A. H. No Effects of Caffeine on Muscle Hypertrophy-Style Resistance Exercise. J Caffeine Res 2011;1(2):117-121. Fuglsang, G., Nielsen, K., Kjaer, Nielsen L., Sennels, F., Jakobsen, P., and Thelle, T. The effect of caffeine compared with theophylline in the treatment of idiopathic apnea in premature infants. Acta Paediatr.Scand. 1989;78(5):786-788. View abstract. In addition, high intake may increase the likelihood of developing incontinence in people with healthy bladders. In a small study, when five healthy adults drank caffeinated water, they experienced a relaxation of the muscle that keeps stomach contents from moving up into the throat — the hallmark of GERD ( 25).Henderson-Smart, D. J. and Davis, P. G. Prophylactic methylxanthines for extubation in preterm infants. Cochrane.Database.Syst.Rev. 2003;(1):CD000139. View abstract. One large study looked at the effects of high caffeine intake on incontinence in more than 65,000 women without incontinence. Heffernan, T. P., Kawasumi, M., Blasina, A., Anderes, K., Conney, A. H., and Nghiem, P. ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine. J Invest Dermatol. 2009;129(7):1805-1815. View abstract.