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However, we should note that historical knowledge is generally fragmented, with different levels of accuracy across each Mediterranean country. The accuracy of historical maps can be questioned, both in terms of survey methods and restitution issues 14, meaning that the percentage loss could be underestimated or overestimated. Our approach involved importing historical maps within a GIS system, scrutinizing the description of meadows’ limits and patterns, finding related scientific literature and observing the current maps, including considerations about the widespread presence of dead matte. This approach represents an effective way to combine information from different perspectives and quantify signs of an ongoing regression. UNEP-WCMC and Short, F. T., Global distribution of seagrasses (version 2). Updated version of the data layer used in Green and Short (2003). (2005) Available at: http://data.unep-wcmc.org/datasets/. (Accessed: 25 th February 2015). Fowlkes, E.B. & Mallows, C.L. A method for comparing 2 hierarchical clusterings. J. Am. Stat. Assoc. 78, 553–569 (1983). Thirty sTBI inpatients were enrolled based on consecutive sampling within a six-month time window. This sample size met the minimum requirement set by an a priori power analysis for nonparametric between-group comparisons conducted on preliminary data (α = 0.05; β = 0.8; ES = 0.6) [ 30]. According to this sample size estimation procedure, each group should have had at least 13 patients. All participants were at their first neurorehabilitation admission since trauma. Almost all the patients selected suffered from sTBI as a consequence of a traffic accident, whereas two people suffered from sTBI due to a fall off a horse. Inclusion criteria were: aged between 15 and 65 years, Level of Cognitive Functioning (LCF) ≥ 7 [ 31]. Prior traumatic brain injury, cognitive deficits affecting comprehension of task instructions (Mini-Mental State Examination score of 24), severe unilateral spatial neglect (diagnosed using a battery of tests including the Letter Cancellation Test, Barrage Test, Sentence Reading Test, and Wundt–Jastrow Area Illusion Test), and severe aphasia, the presence of other neurological and psychiatric diseases, and the presence of orthopaedic or cardiac comorbidities that would limit participation in the experimental and conventional training were the exclusion criteria.

Concerning the follow-up period, we did not use a specific algorithm to choose a period of 8 weeks for the follow-up; we rather considered this time window as appropriate to better understand the post-trial effects and the maintenance of gains outside the hospital. Indeed, this time period of follow-up is consistent with a previous clinical trial aimed at investigating the effects of VR in highly disabled patients on their activities of daily living after discharge [ 25]. Boudouresque, C. F. et al. in Protection and conservation of Posidonia oceanica meadows 202 pp. (RAMOGE & RAC/SPA, 2012).

Funding

Calabrese, A. & Paninski, L. Kalman filter mixture model for spike sorting of non-stationary data. J. Neurosci. Methods 196, 159–169 (2011). Falace, A., Kaleb, S. & Curiel, D. Implementazione dei SIC marini italiani: nuove proposte per il Friuli Venezia Giulia. Biol. Mar. Mediterr. 16, 82–83 (2009).

Bonacorsi, M., Pergent-Martini, C., Breand, N. & Pergent, G. Is Posidonia oceanica regression a general feature in the Mediterranean Sea? Mediterr. Mar. Sci. 14, 193–203 (2013). Marba, N. et al. Effectiveness of protection of seagrass ( Posidonia oceanica) populations in Cabrera National Park (Spain). Environ. Conserv. 29, 509–518 (2002). Guillen, J. E. et al. Evolution of Posidonia oceanica seagrass meadows and its implications for management. J. Sea Res. 83, 65–71 (2013). Gonzalez-Correa, J. M., Bayle Sempere, J. T., Sanchez-Jerez, P. & Valle, C. Posidonia oceanica meadows are not declining globally. Analysis of population dynamics in marine protected areas of the Mediterranean Sea. Mar. Ecol-Prog. Ser. 336, 111–119 (2007).

Costantino, G. et al. Distribution and bio-ecological features of Posidonia oceanica meadows along the coasts of the southern Adriatic and northern Ionian Seas. Chem. Ecol. 26, 91–104 (2010). Another limitation is the absence of an instrumental evaluation of the vestibular reflexes’ functions [ 55, 56], but, even in a probable absence of specific vestibular damage for the enrolled sample, VR was not expected to lead to improvements in vestibular reflexes. In fact, it seems rather to act as a facilitator for improving a compensation strategy based on the enhancement of the vestibular network and sensory–motor integration for managing a correct trade-off between stability and advancement during gait. Institute of Oceanography, Hellenic Centre for Marine Research, PO box 2214, Heraklion, Crete, 71003, Greece In Egypt, P. oceanica meadows are present along the western coast down to the Abu-Quir Bay. The absence of beds in the eastern part could be explained through a decrease of salinity and water transparency due to the considerable freshwater input from the Nile’s Delta.

Ardizzone, G., Belluscio, A. & Maiorano, L. Long-term change in the structure of a Posidonia oceanica landscape and its reference for a monitoring plan. Mar. Ecol-Prog. Ser. 27, 299–309 (2006). Mayot, N., Boudouresque, C. F. & Leriche, A. Unexpected response of the seagrass Posidonia oceanica to a warm-water episode in the North Western Mediterranean Sea. C. R. Biologies 328, 291–296 (2005). El Lakhrach, H., Hattour, A., Jarbouio, O., Elhasni, K. & Ramos-Espala, A. A. Spatial distribution and abundance of the megabenthic fauna community in Gabes Gulf (Tunisia, eastern Mediterranean Sea). Mediterr. Mar. Sci. 13, 12–29 (2012). GSK will account for the transaction as a business combination and expects it to be accretive to adjusted EPS in 2027, the expected first full year of camlipixant’s sales.

Finally, Schueren et al. explored the role of a somatosensory illusion influencing the postural after-effects of standing on an inclined surface. Using a force plate, the authors showed that lower extremity manipulation is a useful intervention to treat postural stability. This study contributes to the growing body of evidence that manipulation of the lower extremities can drive global postural changes, as well as influence standing behavior. Bouveyron, C. & Brunet-Saumard, C. Model-based clustering of high-dimensional data: a review. Comput. Stat. Data Anal. 71, 52–78 (2014). The acquisition of BELLUS is highly synergistic with GSK’s expertise in respiratory medicines and is further supported by GSK’s leading R&D, manufacturing, and commercialisation capabilities.