LEGO 40573 2 in 1 Christmas Tree Eye Catching Festive Holiday Display Build 1 Large or 2 Smaller Trees With Star on Top 12+ 784 Pieces

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Choose either the single large Christmas Tree to make a grand statement - or the two smaller trees and light them both independently of each other with the two separate USB Power Cables included. 2-in-1 means twice the fun!In contrast, for mDA neurons generated on the 3D platform we noted increased survival of transplanted human cells (HNA positive) and maintenance of the midbrain dopaminergic phenotype ( Fig. 4o). Specifically, 82300 ± 20900 HNA+ cells survived, corresponding to 35.6% of implanted cells. Of these, 22.8%, or 18900 ± 4800 cells were TH positive. We therefore observed a substantial 40-fold increase in the total number of cells surviving and a 30-fold increase in the number of TH+ neurons surviving. Furthermore, 22.2% of the surviving HNA+ cells were FOXA2 positive in the 2D controls, whereas 52.6% were FOXA2 positive in the 3D generated mDA neurons. This percentage, in combination with a higher overall survival rate for 3D generated neurons, resulted in 96-fold more FOXA2 positive cells surviving in the 3D grafts compared to the 2D controls. In addition, within the 3D graft, 46.7% of the FOXA2 positive cells were also TH positive, and all of the TH positive cells also expressed FOXA2. The latter result is especially significant as several previous studies have demonstrated the importance of FOXA2 expression in mDA neurons for maintenance of the A9 regional phenotype and overall survival 1, 37, 38.