HAZET 2250-3 31 mm Adapter - Chrome-Plated

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Zhang Z. J., Zhang S. L., Yao Q. L., Feng G., Zhu M. H., Lu Z. H., Inorg. Chem. Front., 2018, 5, 370 The 2250 was housed in a desk with an alphanumeric ( QWERTY) keyboard and a separate programmed function keyboard which had keys, indicator lights and switches. A plastic overlay label could be placed over the function keyboard. Punches on the top edge of the overlay could be sensed by the computer so the keys, lights and switches could be reprogrammed simply by changing overlays. The 2250s CRT measured 21" diagonal, but the useful display area was 12inch by 12inch. A light pen was provided as a pointing device, serving the function of the modern computer mouse. Zhang W. N., Lu G., Cui C. L., Liu Y. Y., Li S. Z., Yan W. J., Xing C., Chi Y. R., Yang Y. H., Huo F. W., Adv. Mater., 2014, 26, 4056 Wang L, Zheng J, Yang S, Wu C, Liu C, Xiao Y, Li Y, Qing Z, Yang R (2015) Two-photon sensing and imaging of endogenous biological cyanide in plant tissues using graphene quantum dot/gold nanoparticle conjugate. ACS Appl Mater Interfaces 7:19509–19515

McLean AM, Socher E, Varnavski O, Clark TB, Imperiali B, Goodson T (2013) Two-photon fluorescence spectroscopy and imaging of 4-Dimethylaminonaphthalimide peptide and protein conjugates. J Phys Chem B 117:15935–15942 Li L. Y., Li Z. X., Yang W. J., Huang Y. M., Huang G., Guan Q. Q., Dong Y. M., Lu J. L., Yu S. H., Jiang H. L., Chem, 2021, 7, 686 Andrade CD, Yanez CO, Ahn H-Y, Urakami T, Bondar MV, Komatsu M, Belfield KD (2011) Two-photon fluorescence vascular bioimaging with new bioconjugate probes selective toward the vascular endothelial growth factor receptor 2. Bioconjug Chem 22:2060–2071 A reduction of the transcriptional activity of NF‐κB was apparent in both Panc Tul and BxPC3 cell lines by the change in expression of cyclin D1 and Bcl2. This is testimony to the functional relevance of NF‐kB inhibition by GP‐2250. The expression of cyclin D1, the driver of cell cycle progression, was reduced by GP‐2250 (Figure 5). This finding is in line with the previously shown reduction of the rate of cell proliferation by GP‐2250. 1 The expression of the anti‐apoptotic protein Bcl2 was likewise reduced by GP‐2250 (Figure 6). Thus, by inhibiting NF‐κB, GP‐2250 is able to disrupt tumour progression in a two‐pronged manner, by reducing the rate of cell proliferation and promoting apoptosis.

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Nag A, Goswami D (2009) Solvent effect on two-photon absorption and fluorescence of rhodamine dyes. J Photochem Photobiol A Chem 206:188–197

Lang R., Du X. R., Huang Y. K., Jiang X. Z., Zhang Q., Guo Y. L., Liu K. P., Qiao B. T., Wang A. Q., Zhang T., Chem. Rev., 2020, 120, 11986

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Shen H. Y., Zhao H. H., Yang J., Zhao J., Yan L., Chou L. J., Song H. L., New J. Chem., 2022, 46, 3095 De Boni L, Piovesan E, Misoguti L, Zílio SC, Mendonca CR (2007) Two-photon absorption dependence on the temperature for Azoaromatic compounds: effect of molecular conformation. J Phys Chem A 111:6222–6224 Impact of GP‐2250 on ATP level. Structure of GP‐2250 (A). Decrease of ATP in BxPC3 cells and (B) Panc Tul cells (C) compared to cell viability (MTT test) following incubation with GP‐2250 (250 and 500μM) for 6h. The level of ATP and cell viability were assessed in the same test samples. MTT, 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5 diphenyltetrazoliumbromid; NC, negative control.** p≤0.01; *** p≤0.001. The IBM 2250 Graphics Display Unit was a vector graphics display system by IBM for the System/360; the Model IV attached to the IBM 1130.