PREMIER SEEDS DIRECT - Perilla - SHISO - Green - 2 Gram ~ Approx 1733 Seeds

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Wang, Z.X.; Lin, Q.Q.; Tu, Z.C.; Zhang, L. The influence of in vitro gastrointestinal digestion on the Perilla frutescens leaf extract: Changes in the active compounds and bioactivities. J. Food Biochem. 2020, 44, e13530. [ Google Scholar] [ CrossRef]

Wahle, K.W.; Brown, I.; Rotondo, D.; Heys, S.D. Plant phenolics in the prevention and treatment of cancer. Adv. Exp. Med. Biol. 2010, 698, 36–51. [ Google Scholar] [ CrossRef] [ PubMed]If you prefer container gardening and would still like to grow perilla, be sure the container is large enough to support the plant’s size and root system. Caring for Perilla Rust is another slight concern with perilla. This disease is exactly what it sounds like. The perilla plant will begin to have spots appear on it which resemble a rust color. Zhou, X.J.; Yan, L.L.; Yin, P.P.; Shi, L.L.; Zhang, J.H.; Liu, Y.J.; Ma, C. Structural characterisation and antioxidant activity evaluation of phenolic compounds from cold-pressed Perilla frutescens var. arguta seed flour. Food Chem. 2014, 164, 150–157. [ Google Scholar] [ CrossRef] Thomas, S.S.; Cha, Y.S.; Kim, K.A. Protective Effect of Diet-Supplemented and Endogenously Produced Omega-3 Fatty Acids against HFD-Induced Colon Inflammation in Mice. Foods 2022, 11, 2124. [ Google Scholar] [ CrossRef] Masahiro, T.; Risa, M.; Harutaka, Y.; Kazuhiro, C. Novel Antioxidants Isolated from Perilla frutescens Britton var. crispa (Thunb.). Biosci. Biotechnol. Biochem. 1996, 60, 1093–1095. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version]

ALA is not as active in the body and must be converted to two other forms of omega-3 fatty acids — eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) — to bestow the same health benefits ( 4). Kwon, S.J.; Lee, J.H.; Moon, K.D.; Jeong, I.Y.; Yee, S.T.; Lee, M.K.; Seo, K.I. Isoegomaketone induces apoptosis in SK-MEL-2 human melanoma cells through mitochondrial apoptotic pathway via activating the PI3K/Akt pathway. Int. J. Oncol. 2014, 45, 1969–1976. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version] The seeds can take anywhere from one to three weeks to germinate. Perilla seeds should be started indoors as most other seeds are. Place them in moist potting soil inside grow trays. Don’t cover the seeds heavily with dirt because they need some light to germinate. Liu, J.; Peng, Y.; Wei, W. Cell cycle on the crossroad of tumorigenesis and cancer therapy. Trends Cell Biol. 2022, 32, 30–44. [ Google Scholar] [ CrossRef] [ PubMed] IK-induced ROS production regulated cell growth inhibition and induced apoptosis through cysteinase-dependent and non-independent pathways by modulating PI2K/AKT signaling in SK-MEL-3 cells. Reduced protein levels of Bax and cytochrome c as well as PARP cleavage, while protein levels of Bcl-2 were increased.It’s important to pay attention to what else is planted near perilla. Where it’s a larger plant, it has a bigger root system. Studies have found that, thanks to their omega-3, fiber, and protein, chia seeds could decrease the risk of chronic disease when consumed as part of a healthy diet. Fatma, H.; Siddique, H.R. Research and Patents Status of Selected Phytochemicals Against Cancer: How Close and How Far? Recent Pat. Anticancer Drug Discov. 2023, 18, 428–447. [ Google Scholar] [ CrossRef]

Paradee, N.; Utama-Ang, N.; Uthaipibull, C.; Porter, J.B.; Garbowski, M.W.; Srichairatanakool, S. Extracts of Thai Perilla frutescens nutlets attenuate tumour necrosis factor-α-activated generation of microparticles, ICAM-1 and IL-6 in human endothelial cells. Biosci. Rep. 2020, 40, BSR20192110. [ Google Scholar] [ CrossRef]

PSO and Ros A scavenge TNF-α induced ROS levels, resulting in reduced expression of MnSOD, FOXO1, NF-κB, and JNK signaling pathways.