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An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician. Use of Natural Products by Children : What the Science Says. NCCIH. https://www.nccih.nih.gov/health/providers/digest/use-of-natural-products-by-children-science Eating garlic raw may provide additional benefits, as some of the beneficial compounds in garlic are sensitive to heat. What happens if I eat garlic every day? Few scientific studies have looked into the effects of garlic on the common cold, but a 2001 study in Advances in Therapy reported that people taking garlic supplements were less likely to catch a cold, and also recovered faster if infected. 8 Lawson LD, et al. (2018). Allicin bioavailability and bioequivalence from garlic supplements and garlic foods.
Hwang KA, et al. (2019). Effects of low temperature-aged garlic on exercise performance and fatigue in Mice. Some drugs that may interact with this product include: protease inhibitors (e.g., indinavir, saquinavir), non-nucleoside reverse transcriptase inhibitors (NNRTIs such as nevirapine, efavirenz), isoniazid, medications/herbal products that may increase your risk of bleeding (e.g., "blood thinners" such as warfarin and heparin, anti-platelet drugs such as clopidogrel, nonsteroidal anti-inflammatory drugs-NSAIDs such as ibuprofen, herbals such as danshen/ginger/gingko).
Ried K, Toben C, Fakler P. Effect of garlic on serum lipids: an updated meta-analysis. Nutr Rev. 2013;71(5):282-99. doi: 10.1111/nure.12012. Garlic oil could be an effective agent or food supplement in reducing the toxicity of tributyltin ( Reference Liu and Xu 25 ). Allicin-mediated lipoperoxide production in fungal plasma membranes is the cause of the enhancement in the cellular uptake of polymyxin B as well as its action against the vacuole ( Reference Ogita, Nagao and Fujita 26 ). Supplementation of garlic oil at 5 mg/kg body weight has been shown to have an anticoagulation effect in an animal study ( Reference Chan, Yin and Chao 27 ). Garlic oil and allyl alcohol, both derived from alliin in garlic using different preparation methods, cause potent growth inhibition in yeasts ( Reference Chung, Kwon and Shim 82 ). The Gram-negative diarrhoeagenic pathogens from stool samples were highly sensitive to garlic, while ciprofloxacin was most effective against Escherichia coli ( Reference Eja, Asikong and Abriba 83 ). The antimicrobial activity was compromised by storage and heating; therefore it is advisable to use fresh garlic and avoid boiling it for more than 5 min during cooking ( Reference Al-Waili, Saloom and Akmal 84 ). Chopped garlic has a slowing-down effect on microbiological growth in ground meat depending on the garlic concentration, but this effect was not at an expected level even at the highest concentration, because potential antimicrobial agents in chopped garlic were probably insufficiently extracted ( Reference Aydin, Bostan and Erkan 85 ). Garlic cloves have antimicrobial properties in vitro against streptococci and anticariogenic properties against oral micro-organisms in spite of their adverse effects ( Reference Groppo, Ramacciato and Motta 86 ). Fresh garlic and garlic powder, through their combined antioxidant and antimicrobial effects, are potentially useful in preserving meat products ( Reference Sallam, Ishioroshi and Samejima 87 ). A wide variety of these organosulfur compounds, whether naturally occurring or synthetic, exhibit antibacterial properties. Mechanistically, organosulfur groups in garlic compounds can act as metal chelators, powerful nucleophiles or electrophiles depending on the local environment in which a given reaction occurs ( Reference Konaklieva and Plotkin 88 ). The smell of Garlic Pearls may be noticeable on the breath and skin. If this is bothersome, use an enteric-coated Garlic Pearls product. Banerjee et al. ( Reference Banerjee, Maulik and Manchanda 118 ) investigated long-term effects of a low-dose garlic extract in an animal model using endogenous antioxidant enzymes and lipid peroxidation in the liver and kidney. Rats were fed with fresh garlic homogenate daily in three different doses (250, 500 and 1000 mg/kg per d) for 30 d. In comparison with saline-treated rats, the 250 mg/kg per d dose resulted in significantly reduced lipid peroxidation and glutathione peroxidase, no change in catalase and reduced glutathione; SOD was increased significantly. Both the 500 and 1000 mg/kg per d doses significantly reduced endogenous antioxidants (catalase and SOD) without altering lipid peroxidation level. Animals treated with 1000 mg/kg per d showed morphological changes in the liver both at light microscopy and ultrastructural levels. Histologically, liver showed focal non-specific injury to the hepatocytes. The reason for such type of injuries could be the sulfoxides present in the garlic extract that can undergo exchange reactions with –SH groups of enzymes and proteins in the body, spontaneously at physiological pH and temperature, inhibiting their activity ( Reference Jocelyn 119 ). Therefore, it seems that garlic in low doses has the potential to enhance the endogenous antioxidant status, although at higher doses a reversal of these effects is observed.
A.A. Myneni et al., Cancer Epidemiology, Biomarkers & Prevention: "Raw Garlic Consumption and Lung Cancer in a Chinese Population." Khuda-Bukhsh AR, Das S, Saha SK. Molecular approaches toward targeted cancer prevention with some food plants and their products: inflammatory and other signal pathways. Nutr Cancer. 2014;66(2):194-205. doi:10.1080/01635581.2014.864420 The 10-minute garlic rule typically refers to how long you should let garlic stand after cutting or crushing it before you cook it. This may maintain some of the allicin, a beneficial but unstable compound in garlic that degrades when fresh garlic is heated. What is the best time to eat garlic? Haghi A, Azimi H, Rahimi R. A Comprehensive Review on Pharmacotherapeutics of Three Phytochemicals, Curcumin, Quercetin, and Allicin, in the Treatment of Gastric Cancer. J Gastrointest Cancer. 2017;48(4):314-320. doi:10.1007/s12029-017-9997-7
What are the side effects of taking garlic supplements?
Enhances Digestion: Garlic pearls may support healthy digestion by stimulating the production of digestive enzymes and promoting a healthy gut microbiome. Regulates Blood Sugar Levels: Garlic pearls may aid in regulating blood sugar levels, making them beneficial for individuals with diabetes or those at risk of developing the condition.
Garlic and its extracts appear to protect against DNA damage in vitro. In animal and epidemiological studies, garlic is associated with a reduced risk of cancer ( Reference Schulz, Lahmann and Boeing 108 ). At least two anti-carcinogenic agents have been identified in garlic: DAS and GST ( Reference Bose, Guo and Zimniak 109 ). In the glandular stomach mucosa of rats, pretreatment with DAS significantly and dose dependently inhibited chemically induced nuclear aberrations and ornithine decarboxylase activity ( Reference Hu 110 ). Similarly, oral administration of a garlic supplement inhibited the development of benzopyrene-induced neoplasia and induced increased GST activity in the forestomach ( Reference Srivastava, Hu and Xia 111 ). In a study, supplementation with high-Se garlic before exposure to a known carcinogen significantly reduced DNA damage, normalised hepatic enzymes, and increased the concentrations of GST and uridine 5′-diphosphate-glucuronyltransferase in the liver and kidney, thus suggesting that garlic may suppress tumour development by enhancing detoxification ( Reference Ip and Disk 112 ). Medical research links garlic to a number of health benefits. However, some studies have suggested that raw garlic may be more effective than the cooked version, while garlic supplements are the most effective. Garlic tea retains the health benefits of raw garlic, as long as it is prepared properly: the key is boiling your crushed garlic no longer than 3 minutes.The research also suggested that the component could reduce heart enlargement in a mouse model of heart failure. Further research is needed to understand the effects on humans. Alare K, Alare T. Open Acc J of Toxicol Review of Toxicity of Allicin From Garlic. Open Acc J of Toxicol. 2020;4(5). doi:10.19080/OAJT.2020.04.555647 Not just for cooking, garlic has all sorts of uses and benefits. Keep reading to find out more! What is garlic and what does it do?
However, throughout ancient history, people widely used garlic for its health and medicinal properties. There is documented evidence of its use by many major civilizations, including the Egyptians, Greeks, Romans, Chinese, and Indians. El-Saber Batiha G, Magdy Beshbishy A, G Wasef L, et al. Chemical Constituents and Pharmacological Activities of Garlic ( Allium sativum L.): A Review. Nutrients. 2020;12(3):872. Published 2020 Mar 24. doi:10.3390/nu12030872 De Greef D, Barton EM, Sandberg EN, et al. Anticancer potential of garlic and its bioactive constituents: a systematic and comprehensive review. Semin Cancer Biol. 2021;73:219-264. doi:10.1016/j.semcancer.2020.11.020 Most fermentation takes place in a warm, humidity-controlled environment where garlic is left for several weeks.Lowers Cholesterol Levels: The active compounds in Garlic Pearls have been shown to reduce LDL (bad) cholesterol levels while increasing HDL (good) cholesterol levels, promoting overall cardiovascular health. Asian countries like Japan, Thailand and South Korea have been using it for centuries – with each country having their own take on the fermentation process. Garlic (both the 10 % homogenate in physiological saline solution and its supernatant fraction) was able to reduce the radicals that were generated by the Fenton reaction and trapped by phenyl-butyl-nitron; radicals present in cigarette smoke were also reduced by garlic ( Reference Torok, Belaggi and Reitz 32 ). In rat liver microsomes, garlic extract prevented the formation of thiobarbituric acid-reactive substances in cell membranes during lipid peroxidation in a dose dependent fashion ( Reference Chang, Yamato and Yamasaki 33 ). An aqueous extract obtained from 1 mg of a garlic preparation was as effective as an antioxidant as 30 nmol ascorbic acid and/or 3·6 nmol α-tocopherol ( Reference Lewin and Popev 34 ). Glycation endproduct formation is increased under conditions of oxidative stress, such as glutathione depletion, and glycated proteins produce 50-fold more toxic free radicals than non-glycated proteins. A recent study suggested that aged garlic extract inhibits the formation of glycation endproducts in vitro and the formation of glycation-derived free radicals ( Reference Ahmad and Ahmed 35 ). Ried K, Fakler P. Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance. Integr Blood Press Control. 2014;7:71-82. Published 2014 Dec 9. doi:10.2147/IBPC.S51434 The analysis noted that the effect of garlic was similar to some blood pressure medications but with fewer side effects.
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