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Höning S, Sandoval IV, von Figura K (Aug 1998). "A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3". The EMBO Journal. 17 (5): 1304–14. doi: 10.1093/emboj/17.5.1304. PMC 1170479. PMID 9482728.

lamp: 5 in 1 or 16 in 1? | Mumsnet Sunset lamp: 5 in 1 or 16 in 1? | Mumsnet

Endo Y, Furuta A, Nishino I. Endo Y, et al. Acta Neuropathol. 2015 Mar;129(3):391-8. doi: 10.1007/s00401-015-1385-4. Epub 2015 Jan 15. Acta Neuropathol. 2015. PMID: 25589223 Review. in 1 appears to have 16 colour choices or rather lighter to darker of 4 colours that adds up to 16. It also doesn't look like it needs filter changes because it is an RGB option so the colours are mixed like on a multi coloured LED strip. It also has 4 settings for steady light, increasing brightness etc. Or at least that's what I understand. Lee N, Wang WC, Fukuda M (Nov 1990). "Granulocytic differentiation of HL-60 cells is associated with increase of poly-N-acetyllactosamine in Asn-linked oligosaccharides attached to human lysosomal membrane glycoproteins". The Journal of Biological Chemistry. 265 (33): 20476–87. doi: 10.1016/S0021-9258(17)30529-X. PMID 2243101. Viitala J, Carlsson SR, Siebert PD, Fukuda M (Jun 1988). "Molecular cloning of cDNAs encoding lamp A, a human lysosomal membrane glycoprotein with apparent Mr approximately equal to 120,000". Proceedings of the National Academy of Sciences of the United States of America. 85 (11): 3743–7. Bibcode: 1988PNAS...85.3743V. doi: 10.1073/pnas.85.11.3743. PMC 280294. PMID 3131762. Lysosomal-associated membrane protein 1 ( LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a ( Cluster of Differentiation 107a), is a protein that in humans is encoded by the LAMP1 gene. The human LAMP1 gene is located on the long arm (q) of chromosome 13 at region 3, band 4 (13q34).PDBe-KB provides an overview of all the structure information available in the PDB for Human Lysosome-associated membrane glycoprotein 1

LAMP-1-deficient Normal Lysosomal Morphology and Function in LAMP-1-deficient

Although the LAMP1 glycoproteins primarily reside across lysosomal membranes, in certain cases they can be expressed across the plasma membrane of the cell. [11] Expression of LAMP1 at the cell surface can occur due to lysosomal fusion with the cell membrane. [12] Cell surface expression of LAMP1 can serve as a ligand for selectins [13] [14] and help mediate cell- cell adhesion. [15] Accordingly, cell surface expression of LAMP1 is seen in cells with migratory or invasive functions, such as cytotoxic T cells, platelets and macrophages. [16] Cell surface expression of LAMP1 and LAMP2 is also often seen in cancer cells, [16] [17] particularly cancers with high metastatic potential, such as colon carcinoma and melanoma, [16] and has been shown to correlate with their metastatic potential. [11] Role in cancer [ edit ]Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2)". Journal of Biological Regulators and Homeostatic Agents. 16 (2): 147–51. PMID 12144129. Immunofluorescence staining of HeLa Cells with antibody to reveal lysosomal LAMP1 in red and vimentin containing intermediate filaments in green. Nuclear DNA is seen in blue. Antibodies and image courtesy EnCor Biotechnology Inc.

LAMP-1 and LAMP-2 in lysosome biogenesis and Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and

a b c Jensen SS, Aaberg-Jessen C, Christensen KG, Kristensen B (2013). "Expression of the lysosomal-associated membrane protein-1 (LAMP-1) in astrocytomas". International Journal of Clinical and Experimental Pathology. 6 (7): 1294–1305. PMC 3693194. PMID 23826410. Wang Y, Cheng B, Lin YJ, Wang R, Xuan J, Xu HM. Wang Y, et al. Toxics. 2023 Sep 9;11(9):765. doi: 10.3390/toxics11090765. Toxics. 2023. PMID: 37755775 Free PMC article. Kima, P. E.; Burleigh, B.; Andrews, N. W. (Dec 2000). "Surface-targeted lysosomal membrane glycoprotein-1 (Lamp-1) enhances lysosome exocytosis and cell invasion by Trypanosoma cruzi". Cellular Microbiology. 2 (6): 477–486. doi: 10.1046/j.1462-5822.2000.00071.x. ISSN 1462-5814. PMID 11207602. S2CID 19192092. Lysosomal-associated membrane protein 1 is a glycoprotein from a family of Lysosome-associated membrane glycoproteins. [5] The LAMP-1 glycoprotein is a type I transmembrane protein [6] which is expressed at high or medium levels in at least 76 different normal tissue cell types. [7] It resides primarily across l ysosomal membranes, [8] and functions to provide selectins with carbohydrate ligands. [5] CD107a has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells, [9] and may also play a role in tumor cell differentiation and metastasis. a b c d e f g h Andrejewski N, Punnonen EL, Guhde G, Tanaka Y, Lüllmann-Rauch R, Hartmann D, von Figura K, Saftig P (Apr 1999). "Normal lysosomal morphology and function in LAMP-1-deficient mice". The Journal of Biological Chemistry. 274 (18): 12692–701. doi: 10.1074/jbc.274.18.12692. PMID 10212251.The Blagdon Inpond 6000 is an instant solution for achieving a healthy, clear and beautiful pond. The pond filter has been designed for ponds up to 6000 litres in size and boasts 5 innovative features merged into one design - all of which remain unmatched when it comes to pond filters on the market right now. The innovation comes complete with 4 stunning fountain heads for a range of breathtaking effects. A low wattage LED spotlight automatically illuminates the pond during nighttime, switching on after dark to provide an eye-catching focal feature for your garden over those long summer nights. Obviously I never heard of such a thing until tonight. Google revealed it's one of those tiktok crazes and I looked at the options. Polylactosamine attachments which protect the glyocoprotein from degradation by lysosomal proteases [10] Clarkson-Paredes C, Karl MT, Popratiloff A, Miller RH. Clarkson-Paredes C, et al. PNAS Nexus. 2023 Oct 12;2(10):pgad334. doi: 10.1093/pnasnexus/pgad334. eCollection 2023 Oct. PNAS Nexus. 2023. PMID: 37901440 Free PMC article. García-Trevijano ER, Ortiz-Zapater E, Gimeno A, Viña JR, Zaragozá R. García-Trevijano ER, et al. Front Cell Dev Biol. 2023 Sep 19;11:1249317. doi: 10.3389/fcell.2023.1249317. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37795261 Free PMC article. Review.