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Product Information

This section provides an overview of the calculated volume at which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. The ‘Hazard classification’ and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information. If no EU harmonised classification and labelling exists and the substance was not registered under REACH, information derived from classification and labelling (C&L) notifications to ECHA under CLP Regulation is displayed under this section. These notifications can be provided by manufacturers, importers and downstream users. ECHA maintains the C&L Inventory, but does not review or verify the accuracy of the information. For readability purpose, only non-confidential use descriptors occurring in more than 5% of total occurrences are displayed.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher’s Note The EC or list number is the primary substance identifier used by ECHA. CAS (Chemical Abstract Service) registry number Mutagenic (M) – Recognised mutagen: comes from a harmonised C&L classifying the substance as Muta. 1A or 1B and/or an entry in the Candidate list. Potential mutagen: comes from a harmonised C&L classifying the substance as a suspected mutagen Muta. 2. Broad agreement: comes from industry data where a majority of data submitters agree the substance is mutagenic. Minority position: comes from industry data where a minority of data submitters indicate the substance is mutagenic. More information about mutagenicity here.

ORIGINAL RESEARCH article

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Optimized to provide maximum life, especially for applications where the end user doesn’t run the engine on a regular basis:At PETER HAHN you will find fashion for men and women, including plus size fashion and an extensive choice of fashion made from natural fibres. Above all, cashmere fashion is our passion as well as our specialty.

Chris Craft; Chrysler Marine; Commander; Crusader; Escort (Skiltec); Gray Marine; Isuzu; Lenco; Marine Power; North American Engine; Onan; Osco Motors; OMC; Perkins Engine U.S.; Plesurecraft Marine; Volvo Penta; The Cylinder Base Gasket 0,4 mm is a genuine spare part manufactured by Piaggio so you have peace of mind the Cylinder Base Gasket 0,4 mm part being sold by Motorcycle Spare Parts is both original and new. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas.

Conclusion

At early stages, the research studies related to the MHC are developed based on mice experiments. With the availability of a large amount of data and development of machine learning, developing a machine learning–based model to research the MHC was feasible. Li et al. (2019) proposed an identification method of the MHC based on an extreme learning machine algorithm. Although high accuracy has been achieved, there are still many aspects worthy of further investigation ( Lv et al., 2019; Lv et al., 2021a; Lv et al., 2021b). In this study, we aim to propose a new MHC predictor, PredMHC, to further improve prediction performance. Materials and Methods Framework of PredMHC As a large locus on vertebrate DNA, the major histocompatibility complex (MHC) contains a tightly linked set of polymorphic genes encoding cell surface proteins that are essential for immune surveillance. These cell surface proteins are called MHC molecules ( Kubiniok et al., 2022). MHC molecules are classified into MHC class I, MHC class II, and MHC class III according to variation in molecular structure, function, and distribution ( Marcoux et al., 2021). MHC class I molecules are expressed in all nucleated cells and platelets—essentially all cells except red blood cells, which display antigens to signal cytotoxic T lymphocytes, including clusters of differentiation (CD8 +) ( McShan et al., 2021). MHC class II molecules are expressed in antigen-presenting cells, such as B cells, dendritic cells, and macrophages, where they normally bind to CD4 + receptors on helper T cells to clear foreign antigens. MHC class III genes are interleaved with class I and class II genes on the short arm of chromosome 6, but their proteins play different physiological roles. The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author. Author Contributions At least one company has indicated that the substance classification is affected by impurities or additives.

Potential" - again comes from official sources only. Potential concerns are illustrated with a light red icon. For (C), (M), and (R) it means that the concern is suspected in a Harmonised C&L (CLP Regulation Annex VI), as Carc. 2, Muta. 2, or Repr. 2. For (PBT) and (ED) Potential means that the concern is under assessment in the PBT or ED assessment list, and the outcome indicates a potential ED. There are no potential (Ss) or (Sr)s. The described Product category (i.e. the products in which the substance may be used) may refer to uses as intermediate and under controlled conditions, for which there is no consumer exposure.

Cummins 6B 300Hp B Series; Cummins C Series; CAT 3208; CAT 3116; CAT 3126; Deere 6076; Sherwood Pump P17 series where N i denotes the number of the ith amino acid in the protein sequence and L denotes the length of a sequence. Obviously, ∑ V i = 1. ED – Recognised Endocrine Disruptor (ED): comes from an entry in the Candidate list. Potential ED: is shown for substances under assessment, and comes from an entry in the ED assessment list, if the outcome is not final and “Not ED”. At this time there is no industry submitted data taken into account to display an ED property of concern. More information about endocrine disrupting substances here. It is possible that a harmonisation is introduced through an amendment to the CLP Regulation. In that case, the ATP (Adaptation to Technical Progress) number is displayed. Hazard statements were adapted to improve readability and may not correspond textually to the hazard statements codes description in the European Union Specific Hazard Statements (EUH) or the UN Global Harmonised System (GHS).