Apigenin 100mg x 90 Capsules - Third Party Tested Over 98% - Natural Apigenin Supplement Vitality Pro

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This flavone is known for its relaxing and sedative effects. It has been shown to reduce cortisol levels, helping prevent the body’s response to chronic stress.

Animal studies suggest that apigenin improves insulin resistance and can be helpful for people with diabetes. One report found that the flavone improved impaired glucose tolerance and significantly decreased insulin resistance. 8. Works as an Anticancer Agent

Author Contributions

Yiqing Song, JoAnn E Manson, Julie E Buring, Howard D Sesso, Simin Liu Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis J Am Coll Nutr. (2005 Oct) All the current research suggests that Apigenin is safe, even at doses exceeding what you would usually require through diet alone. However, if you experience any sort of digestive issues or irritations following ingesting, you should stop using the product. Speak to a healthcare professional before using Apigenin to treat a condition. Can women take Apigenin? Jameie SB, Pirasteh A, Naseri A, Jameie MS, Farhadi M, Babaee JF, Elyasi L β-Amyloid Formation, Memory, and Learning Decline Following Long-term Ovariectomy and Its Inhibition by Systemic Administration of Apigenin and β-Estradiol. Basic Clin Neurosci. (2021) Panda and Kar [ 110] confirmed the capacity of apigenin in regulating hyperglycemia, thyroid dysfunction, and lipid peroxidation in a diabetic animal model [ 110]. The administration of apigenin to alloxan-treated mice also suggested the hepatoprotective role of this nutraceutical compound, attributed to its capacity to increase the activity of cellular antioxidants, such as catalase (CAT) and superoxide dismutase (SOD), and glutathione (GSH). Similar results have been reported by Ren et al. [ 84], who demonstrated decreased levels of blood glucose, serum lipid, malonaldehyde, intercellular adhesion molecule-1, and insulin resistance index, increased SOD activity, and improved impaired glucose tolerance of apigenin when compared to a diabetic control group.

Several natural bioactive compounds for improving learning and memory, as well as some active and passive anti-amyloid-β and anti-tau immunotherapies using synthetic peptides or monoclonal antibodies (mAb), have been reported as promising candidates for further treatment of patients with Alzheimer’s disease [ 113, 114, 115, 116]. Bevilacqua L, Buiarelli F, Coccioli F, Jasionowska R Identification of compounds in wine by HPLC-tandem mass spectrometry. Ann Chim. (2004) Apigenin is practically insoluble in highly polar solvents such as water (0.00135 mg/mL), and nonpolar solvents such as silicon fluid (0.0728 mg/mL) and safflower oil (0.0317 mg/mL) [ 15, 16]. Other reports on apigenin’s solubility in aqueous solutions show that it ranges from 0.001 to 1.63 mg/mL in nonpolar solvents [ 6] and 2.16 μg/mL in phosphate buffer at pH 7.5 [ 31]. Apigenin is freely soluble in dimethylsulfoxide (DMSO) [ 11]. One source estimated the solubility to be more than 100 mg/mL [ 16], while another showed that the approximate solubility of apigenin in ethanol, DMSO, and dimethylformamide (DMF) purged with inert gas to be 0.3, 15, and 25 mg/mL [ 32]. Flavonoids are also more soluble in methanol than in water [ 33]. As a result, organic solvents like DMSO [ 34] and Tween 80 [ 31] are used to dissolve apigenin prior to their addition to an aqueous solution to increase solubility. Different carriers such as ethosomes [ 35], polymeric micelles of Pluronic P123 and Solutol HS 15 [ 36], and carbon nanopowder [ 37], or self-microemulsifying delivery system [ 38] are also developed and tested to enhance the efficacy of apigenin. Taking into consideration its high permeability, apigenin is categorized as a Class II drug according to Biopharmaceutics Classification System (BCS), whose characteristics are low solubility and high permeability [ 31, 39]. In mice, topical apigenin improved skin permeability barrier function by promoting skin cell growth and the production of fatty molecules and antimicrobial proteins. This suggests it may help with conditions characterized by permeability barrier dysfunction such as atopic dermatitis [ 7]. Apigenin is an antioxidant compound that naturally occurs in plants. It can be found in fruits and vegetables, such as parsley, onions, oranges, tea, chamomile, wheat sprouts, and some seasonings. Outside of its biological effects, it is a yellow crystalline that is typically used to dye garments.This explains why chamomile tea can have beneficial effects on anxiety and help aid relaxation and sleep. Apigenin is a naturally occurring compound found in some fruits, vegetables and herbs. Due to its function within humans, it is classified as an antioxidant flavonoid. Flavonoids play a vital role in keeping us healthy whilst preventing the development of chronic diseases, such as cardiovascular disease and dementia. Flavonoids also promote good health due to having antibacterial, antiparasitic, antiviral and antifungal properties. Apigenin in particular has specific and exclusive benefits, due to its biological structure. What does Apigenin do?